Domperidone further reduce cystic area in <i>Pkd1</i>^{<i>–/–</i>}mice following longterm treatment.

Tamoxifen treated Pkd1loxP/loxP EsrCre mice were injected with 10 mg/kg domperidone or same volume of DMSO from P12-P42 and the kidneys were dissected on P43. (A, B) Representative H&E stained kidney sections of domperidone treated (B) or vehicle treated (A) mice from the same litter show a reduction in cystic area in domperidone treated mice. (C) Percentage of cystic area over total kidney section area normalized to control group is shown in the bar plot. Shown are mean ± SEM of all sections quantified for each group. *, P<0.005 compared with control. n = 2 mice for DMSO and n = 3 mice for domperidone-treated group (both kidneys were used in quantification for each animal). (D) Representative kidney sections showing dilation of Bowman’s capsules in vehicle-treated, which is reduced in domperidone-treated mice (E, F). Scale bars: 1mm (A and B), 50 μm (D, E and F).