Voxel based analyses for fractional anisotropy (FA) and apparent diffusion coefficient (ADC) detected increased FA and decreased ADC in trained reachers relative to controls.

These occurred mostly in caudal regions such as the cerebellum and brainstem (ADC), but largely missed the motor and sensory cortices, although decreased ADC values were detected in the corpus callosum, below M1. Results are presented as tmaps, FDR cluster-corrected for multiple comparisons using an initial cluster forming threshold of 0.05 significance, and the whole brain as a mask. Uncorrected statistical maps are also shown in yellow, suggesting microstructural changes in the hippocampus and isocortex.