Figure S4. Relative TNC expression differs across single-cell subpopulations. Single cell RNA-Seq of H3K27 M mutant pediatric glioma was performed by Filbin et al. [23], revealing three tumor cell subpopulations with distinct gene expressions and developmental hierarchy: oligodendrocyte precursor (OPC-like), oligodendrocyte (OC-like), and astrocytic (AC-like) cells. Subgroup analysis of these data revealed TNC as a top expressed gene in AC-like cells (3.717log2 TPM), with statistically significantly greater TNC expression in AC-like cells compared to other cell populations, regardless of PDGFRA amplification status (***p = 0.0002). Y-axis: mean gene expression (in log2 TPM/10). Error bars represent standard error of the mean. Relative gene ...
PCA loadings for human TAMs. Loadings of the 237 genes used in the PCA of Fig. 3a. (XLSX 22 kb
Figure S2. IFN-γ score is an efficient candidate for prognostic indicator of glioma. (A) The express...
Differentially expressed genes in pediatric brain tumors (tumor groups withâ>â3 samples). (XLSX ...
Figure S2. Targeted gene expression analysis in pediatric glioma cell lines. Levels of TNC and relat...
Figure S1. TNC expression in pediatric glioma cell lines modified via shRNA and cDNA transfection in...
Figure S3. Unsupervised hierarchical clustering of cell line gene expression profiles RNA-Seq analys...
Online Resource 2. Differential gene expression analysis of RNA-Seq data Resulting transcriptomes of...
Figure S4. Expression of SGmic genes in glioma-associated microglia as compared to healthy microglia...
Figure S1. (A) ITGB4 mRNA expression in brain tissues (n = 23) and diffuse astrocytoma tissues (n = ...
Table S1. 16 autocrine ligand-receptor pairs with significant Spearmanâs correlation coefficients ...
RT-qPCR confirms (a) up-regulation of CDKN1A and IGFBP7, (b) up-regulation of CDKN2A, IL6 and IL8 an...
The differential expressive genes between U87 and U251 glioma cell lines. (A) Heatmap showed the dif...
Isolation and identification of GSCs. A. a, c: Cells grew into spheres in serum-free medium. b, d: S...
Differentially expressed microRNAs in pediatric brain tumors (tumor groups withâ>â3 samples). (X...
Table S1. Differential expression analysis. List of differentially up- and downregulated genes in th...
PCA loadings for human TAMs. Loadings of the 237 genes used in the PCA of Fig. 3a. (XLSX 22 kb
Figure S2. IFN-γ score is an efficient candidate for prognostic indicator of glioma. (A) The express...
Differentially expressed genes in pediatric brain tumors (tumor groups withâ>â3 samples). (XLSX ...
Figure S2. Targeted gene expression analysis in pediatric glioma cell lines. Levels of TNC and relat...
Figure S1. TNC expression in pediatric glioma cell lines modified via shRNA and cDNA transfection in...
Figure S3. Unsupervised hierarchical clustering of cell line gene expression profiles RNA-Seq analys...
Online Resource 2. Differential gene expression analysis of RNA-Seq data Resulting transcriptomes of...
Figure S4. Expression of SGmic genes in glioma-associated microglia as compared to healthy microglia...
Figure S1. (A) ITGB4 mRNA expression in brain tissues (n = 23) and diffuse astrocytoma tissues (n = ...
Table S1. 16 autocrine ligand-receptor pairs with significant Spearmanâs correlation coefficients ...
RT-qPCR confirms (a) up-regulation of CDKN1A and IGFBP7, (b) up-regulation of CDKN2A, IL6 and IL8 an...
The differential expressive genes between U87 and U251 glioma cell lines. (A) Heatmap showed the dif...
Isolation and identification of GSCs. A. a, c: Cells grew into spheres in serum-free medium. b, d: S...
Differentially expressed microRNAs in pediatric brain tumors (tumor groups withâ>â3 samples). (X...
Table S1. Differential expression analysis. List of differentially up- and downregulated genes in th...
PCA loadings for human TAMs. Loadings of the 237 genes used in the PCA of Fig. 3a. (XLSX 22 kb
Figure S2. IFN-γ score is an efficient candidate for prognostic indicator of glioma. (A) The express...
Differentially expressed genes in pediatric brain tumors (tumor groups withâ>â3 samples). (XLSX ...