Additional file 2: of Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven development of pancreatic cancer

Figure S1. TGIF1 downregulation is associated with tumor progression in human PDAC. Figure S2. Knockdown of TGIF1 displays resistant to TGFβ1 mediated growth inhibition in PDAC. Figure S3. TGIF1 loss exhibits increased in vivo tumorigenic potential of PDAC cells in an allogeneic tumor graft model. Figure S4. Knockdown of TGIF1 enhances tumor sphere forming and migratory abilities in human Panc-1 PDAC cells. Figure S5. Inactivation of TGIF1 upregulated HAS2 and ETV1 expression in human pancreatic tissues as determined by IHC analysis. Figure S6. Knockdown of ETV1 or HAS2 inhibits CD44 expression and reduces in vitro cell migration in PKTP 3067 cells. (DOCX 18253 kb