MOESM11 of ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia

Additional file 11. Gene annotations enriched among ALS-increased DEGs. (A) Gene Ontology biological processes. (B) Gene Ontology cell components. (C) Gene Ontology molecular functions. (D) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. (E) Reactome pathway database. (F) Disease Ontology. (G) Molecular signatures database (MSigDB). (H) Pathway commons. In (A)–(H), enrichment was evaluated with respect to 580 ALS-increased DEGs (FC > 1.10 with FDR < 0.10). The 12 most significantly over-represented annotations are listed for each analysis (Fisher’s exact test or conditional hypergeometric test). The number of genes associated with each annotation is listed in parentheses, and exemplar ALS-increased genes associated with each annotation are shown. In part (G), MSigDB annotations correspond to gene sets generated from the comparison of two sample groups (X|Y), with genes in each set having higher expression in group X as compared to group Y