Additional file 1: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Kim van Pul (6727361)
Ronald Vuylsteke (6727367)
Rieneke van de Ven (434760)
Elisabeth te Velde (6727376)
Emiel Rutgers (3822181)
Petrousjka van den Tol (6727382)
Hein Stockmann (6727388)
Tanja de Gruijl (3539363)

Publication date

May 2019

DOI

10.6084/m9.figshare.8172620.v1

Abstract

Table S1. Phenotype of immune cell subsets. An overview of the used phenotypic definitions for each of the assessed immune subsets and analyzed activation/checkpoint molecules (PDF 510 kb

Extracted data

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Data Protection

Additional file 1: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Kim van Pul (6727361)
Ronald Vuylsteke (6727367)
Rieneke van de Ven (434760)
Elisabeth te Velde (6727376)
Emiel Rutgers (3822181)
Petrousjka van den Tol (6727382)
Hein Stockmann (6727388)
Tanja de Gruijl (3539363)

Open link

Publication date

May 2019

DOI

10.6084/m9.figshare.8172620.v1

Abstract

Table S1. Phenotype of immune cell subsets. An overview of the used phenotypic definitions for each of the assessed immune subsets and analyzed activation/checkpoint molecules (PDF 510 kb

Extracted data

Kar-Tong Tan (3811105)
Ling-Wen Ding (3811114)
Qiao-Yang Sun (3811123)
Zhen-Tang Lao (3811120)
Wenwen Chien (3811111)
Xi Ren (2809030)
Jin-Fen Xiao (5809157)
Xin Loh (5809160)
Liang Xu (102656)
Michael Lill (3811102)
Anand Mayakonda (3811108)
De-Chen Lin (3811117)
Henry Yang (204980)
H. Koeffler (3586466)

October 2018

Figure S1. Expression of CD19/CD20, CD79A/B and RAG1/RAG2 in blood cancer cell lines. X axis: 164 bl...

Additional file 1: of Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

Francesca Finotello (5803820)
Clemens Mayer (6737843)
Christina Plattner (6737846)
Gerhard Laschober (6737849)
Dietmar Rieder (3631147)
Hubert Hackl (15768)
Anne Krogsdam (2559910)
Zuzana Loncova (6737852)
Wilfried Posch (249579)
Doris Wilflingseder (249602)
Sieghart Sopper (823900)
Marieke Ijsselsteijn (6737855)
Thomas Brouwer (6689672)
Douglas Johnson (302588)
Yaomin Xu (221417)
Yu Wang (12152)
Melinda Sanders (6737858)
Monica Estrada (219127)
Paula Ericsson-Gonzalez (6737861)
Pornpimol Charoentong (849763)
Justin Balko (4424944)
Noel Filipe da Cunha Carvahlo de Miranda (6737864)
Zlatko Trajanoski (15774)

May 2019

quanTIseq signature matrix and used RNA-seq data from purified/enriched immune cells. RNA-seq data: ...

Additional file 3: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Kim van Pul (6727361)
Ronald Vuylsteke (6727367)
Rieneke van de Ven (434760)
Elisabeth te Velde (6727376)
Emiel Rutgers (3822181)
Petrousjka van den Tol (6727382)
Hein Stockmann (6727388)
Tanja de Gruijl (3539363)

May 2019

Figure S2. Frequency and activation state of DC subsets in HLN compared to metastasis negative (SLN-...

Additional file 2: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Kim van Pul (6727361)
Ronald Vuylsteke (6727367)
Rieneke van de Ven (434760)
Elisabeth te Velde (6727376)
Emiel Rutgers (3822181)
Petrousjka van den Tol (6727382)
Hein Stockmann (6727388)
Tanja de Gruijl (3539363)

May 2019

Figure S1. Flowcytometric gating of cell subsets. Gating strategies for the DC subsets as well as Tr...

Additional file 6: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Kim van Pul (6727361)
Ronald Vuylsteke (6727367)
Rieneke van de Ven (434760)
Elisabeth te Velde (6727376)
Emiel Rutgers (3822181)
Petrousjka van den Tol (6727382)
Hein Stockmann (6727388)
Tanja de Gruijl (3539363)

May 2019

Figure S5. Frequencies and expression of surface molecules of DC subsets in relation to BrC subtype ...

Additional file 5: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Kim van Pul (6727361)
Ronald Vuylsteke (6727367)
Rieneke van de Ven (434760)
Elisabeth te Velde (6727376)
Emiel Rutgers (3822181)
Petrousjka van den Tol (6727382)
Hein Stockmann (6727388)
Tanja de Gruijl (3539363)

May 2019

Figure S4. TLR7 and TLR8 expression in LN DC subsets and R848-induced activation in tumor negative B...

Additional file 4: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Kim van Pul (6727361)
Ronald Vuylsteke (6727367)
Rieneke van de Ven (434760)
Elisabeth te Velde (6727376)
Emiel Rutgers (3822181)
Petrousjka van den Tol (6727382)
Hein Stockmann (6727388)
Tanja de Gruijl (3539363)

May 2019

Figure S3. Prognostic effect of LNRcDC CD86 expression levels. Kaplan Meier curves of estimated DFS ...

Additional file 1: Table S3. of Tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (Th1, Th2) to immune-mediated tumour cell death induced by NAC

Viriya Kaewkangsadan (4816371)
Chandan Verma (4816380)
Jennifer Eremin (4816374)
Gerard Cowley (4816377)
Mohammad Ilyas (217478)
Oleg Eremin (2621164)

February 2018

Patient and Tumour Characteristics, Responses to Neoadjuvant Chemotherapy (nâ=â33). (DOCX 56Â kb

Additional file 5: of Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients

Gaurav Chatterjee (5998253)
Trupti Pai (5998256)
Thomas Hardiman (5876474)
Kelly Avery-Kiejda (3534812)
Rodney Scott (279337)
Jo Spencer (267903)
Sarah Pinder (553692)
Anita Grigoriadis (41195)

November 2018

Table S5. Differentially expressed genes representing specific immune cell populations across all th...

Additional file 1: of Activated innate lymphoid cell populations accumulate in human tumour tissues

Maryam Salimi (296922)
Ruozheng Wang (655678)
Xuan Yao (344579)
Xi Li (19208)
Xiyan Wang (457117)
Yuhui Hu (7203)
Xumei Chang (5023001)
Peiwen Fan (3536114)
Tao Dong (15551)
Graham Ogg (341111)

March 2018

Figure S1. Representative staining of ILC populations. ILC were gated on lineage negative, CD45+, CD...

Additional file 1: of Dissimilar patterns of tumor-infiltrating immune cells at the invasive tumor front and tumor center are associated with response to neoadjuvant chemotherapy in primary breast cancer

Lisa König (3580973)
Fabian Mairinger (6279713)
Oliver Hoffmann (3580964)
Ann-Kathrin Bittner (3580961)
Kurt Schmid (3491198)
Rainer Kimmig (58539)
Sabine Kasimir-Bauer (3580967)
Agnes Bankfalvi (284668)

February 2019

Figure S1. Representative immunohistochemistry (IHC) staining images for CD8, CD4, CD20 and CD68. Im...

Additional file 1: of Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

Stefanie Wculek (6566330)
JoaquĂn Amores-Iniesta (6566342)
Ruth Conde-Garrosa (6566336)
SofĂa Khouili (6566345)
Ignacio Melero (81908)
David Sancho (5117801)

April 2019

Figure S1. Isolation and phenotypic analysis of cDC1s from the spleen of FLT3L-expressing B16 tumor-...

Additional file 1: Table S1. of An immune stratification reveals a subset of PD-1/LAG-3 double-positive triple-negative breast cancers

Giulia Bottai (3405773)
Carlotta Raschioni (3405758)
Agnese Losurdo (3405755)
Luca Di Tommaso (552457)
Corrado Tinterri (3405761)
Rosalba Torrisi (3405770)
Jorge Reis-Filho (3405767)
Massimo Roncalli (17647)
Christos Sotiriou (643)
Armando Santoro (11245)
Alberto Mantovani (287283)
Sherene Loi (52471)
Libero Santarpia (3405764)

December 2016

Patient characteristics. Table S2. Antibodies and immunostaining protocols. Table S3. Associations b...

Additional file 1: of Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines

Kar-Tong Tan (3811105)
Ling-Wen Ding (3811114)
Qiao-Yang Sun (3811123)
Zhen-Tang Lao (3811120)
Wenwen Chien (3811111)
Xi Ren (2809030)
Jin-Fen Xiao (5809157)
Xin Loh (5809160)
Liang Xu (102656)
Michael Lill (3811102)
Anand Mayakonda (3811108)
De-Chen Lin (3811117)
Henry Yang (204980)
H. Koeffler (3586466)

October 2018

Figure S1. Expression of CD19/CD20, CD79A/B and RAG1/RAG2 in blood cancer cell lines. X axis: 164 bl...

Additional file 1: of Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

Francesca Finotello (5803820)
Clemens Mayer (6737843)
Christina Plattner (6737846)
Gerhard Laschober (6737849)
Dietmar Rieder (3631147)
Hubert Hackl (15768)
Anne Krogsdam (2559910)
Zuzana Loncova (6737852)
Wilfried Posch (249579)
Doris Wilflingseder (249602)
Sieghart Sopper (823900)
Marieke Ijsselsteijn (6737855)
Thomas Brouwer (6689672)
Douglas Johnson (302588)
Yaomin Xu (221417)
Yu Wang (12152)
Melinda Sanders (6737858)
Monica Estrada (219127)
Paula Ericsson-Gonzalez (6737861)
Pornpimol Charoentong (849763)
Justin Balko (4424944)
Noel Filipe da Cunha Carvahlo de Miranda (6737864)
Zlatko Trajanoski (15774)

May 2019

quanTIseq signature matrix and used RNA-seq data from purified/enriched immune cells. RNA-seq data: ...

Additional file 3: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Kim van Pul (6727361)
Ronald Vuylsteke (6727367)
Rieneke van de Ven (434760)
Elisabeth te Velde (6727376)
Emiel Rutgers (3822181)
Petrousjka van den Tol (6727382)
Hein Stockmann (6727388)
Tanja de Gruijl (3539363)

May 2019

Figure S2. Frequency and activation state of DC subsets in HLN compared to metastasis negative (SLN-...

Additional file 2: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Kim van Pul (6727361)
Ronald Vuylsteke (6727367)
Rieneke van de Ven (434760)
Elisabeth te Velde (6727376)
Emiel Rutgers (3822181)
Petrousjka van den Tol (6727382)
Hein Stockmann (6727388)
Tanja de Gruijl (3539363)

May 2019

Figure S1. Flowcytometric gating of cell subsets. Gating strategies for the DC subsets as well as Tr...

Additional file 6: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Kim van Pul (6727361)
Ronald Vuylsteke (6727367)
Rieneke van de Ven (434760)
Elisabeth te Velde (6727376)
Emiel Rutgers (3822181)
Petrousjka van den Tol (6727382)
Hein Stockmann (6727388)
Tanja de Gruijl (3539363)

May 2019

Figure S5. Frequencies and expression of surface molecules of DC subsets in relation to BrC subtype ...

Additional file 5: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Kim van Pul (6727361)
Ronald Vuylsteke (6727367)
Rieneke van de Ven (434760)
Elisabeth te Velde (6727376)
Emiel Rutgers (3822181)
Petrousjka van den Tol (6727382)
Hein Stockmann (6727388)
Tanja de Gruijl (3539363)

May 2019

Figure S4. TLR7 and TLR8 expression in LN DC subsets and R848-induced activation in tumor negative B...

Additional file 4: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Kim van Pul (6727361)
Ronald Vuylsteke (6727367)
Rieneke van de Ven (434760)
Elisabeth te Velde (6727376)
Emiel Rutgers (3822181)
Petrousjka van den Tol (6727382)
Hein Stockmann (6727388)
Tanja de Gruijl (3539363)

May 2019

Figure S3. Prognostic effect of LNRcDC CD86 expression levels. Kaplan Meier curves of estimated DFS ...

Viriya Kaewkangsadan (4816371)
Chandan Verma (4816380)
Jennifer Eremin (4816374)
Gerard Cowley (4816377)
Mohammad Ilyas (217478)
Oleg Eremin (2621164)

February 2018

Patient and Tumour Characteristics, Responses to Neoadjuvant Chemotherapy (nâ=â33). (DOCX 56Â kb

Additional file 5: of Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients

Gaurav Chatterjee (5998253)
Trupti Pai (5998256)
Thomas Hardiman (5876474)
Kelly Avery-Kiejda (3534812)
Rodney Scott (279337)
Jo Spencer (267903)
Sarah Pinder (553692)
Anita Grigoriadis (41195)

November 2018

Table S5. Differentially expressed genes representing specific immune cell populations across all th...

Additional file 1: of Activated innate lymphoid cell populations accumulate in human tumour tissues

Maryam Salimi (296922)
Ruozheng Wang (655678)
Xuan Yao (344579)
Xi Li (19208)
Xiyan Wang (457117)
Yuhui Hu (7203)
Xumei Chang (5023001)
Peiwen Fan (3536114)
Tao Dong (15551)
Graham Ogg (341111)

March 2018

Figure S1. Representative staining of ILC populations. ILC were gated on lineage negative, CD45+, CD...

Lisa König (3580973)
Fabian Mairinger (6279713)
Oliver Hoffmann (3580964)
Ann-Kathrin Bittner (3580961)
Kurt Schmid (3491198)
Rainer Kimmig (58539)
Sabine Kasimir-Bauer (3580967)
Agnes Bankfalvi (284668)

February 2019

Figure S1. Representative immunohistochemistry (IHC) staining images for CD8, CD4, CD20 and CD68. Im...

Additional file 1: of Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

Stefanie Wculek (6566330)
JoaquĂn Amores-Iniesta (6566342)
Ruth Conde-Garrosa (6566336)
SofĂa Khouili (6566345)
Ignacio Melero (81908)
David Sancho (5117801)

April 2019

Figure S1. Isolation and phenotypic analysis of cDC1s from the spleen of FLT3L-expressing B16 tumor-...

Additional file 1: Table S1. of An immune stratification reveals a subset of PD-1/LAG-3 double-positive triple-negative breast cancers

Giulia Bottai (3405773)
Carlotta Raschioni (3405758)
Agnese Losurdo (3405755)
Luca Di Tommaso (552457)
Corrado Tinterri (3405761)
Rosalba Torrisi (3405770)
Jorge Reis-Filho (3405767)
Massimo Roncalli (17647)
Christos Sotiriou (643)
Armando Santoro (11245)
Alberto Mantovani (287283)
Sherene Loi (52471)
Libero Santarpia (3405764)

December 2016

Patient characteristics. Table S2. Antibodies and immunostaining protocols. Table S3. Associations b...

Additional file 1: of Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines

Kar-Tong Tan (3811105)
Ling-Wen Ding (3811114)
Qiao-Yang Sun (3811123)
Zhen-Tang Lao (3811120)
Wenwen Chien (3811111)
Xi Ren (2809030)
Jin-Fen Xiao (5809157)
Xin Loh (5809160)
Liang Xu (102656)
Michael Lill (3811102)
Anand Mayakonda (3811108)
De-Chen Lin (3811117)
Henry Yang (204980)
H. Koeffler (3586466)

October 2018

Figure S1. Expression of CD19/CD20, CD79A/B and RAG1/RAG2 in blood cancer cell lines. X axis: 164 bl...

Additional file 1: of Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

Francesca Finotello (5803820)
Clemens Mayer (6737843)
Christina Plattner (6737846)
Gerhard Laschober (6737849)
Dietmar Rieder (3631147)
Hubert Hackl (15768)
Anne Krogsdam (2559910)
Zuzana Loncova (6737852)
Wilfried Posch (249579)
Doris Wilflingseder (249602)
Sieghart Sopper (823900)
Marieke Ijsselsteijn (6737855)
Thomas Brouwer (6689672)
Douglas Johnson (302588)
Yaomin Xu (221417)
Yu Wang (12152)
Melinda Sanders (6737858)
Monica Estrada (219127)
Paula Ericsson-Gonzalez (6737861)
Pornpimol Charoentong (849763)
Justin Balko (4424944)
Noel Filipe da Cunha Carvahlo de Miranda (6737864)
Zlatko Trajanoski (15774)

May 2019

quanTIseq signature matrix and used RNA-seq data from purified/enriched immune cells. RNA-seq data: ...

Additional file 1: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Abstract

Extracted data

Additional file 1: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Abstract

Extracted data

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