Rb^LoTem cells reverse lung inflammation in an IL-4-dependent fashion.

Mice were given 60,000 of anti-CD3ε-stimulated WT or IL-4ko RbLoTem cells on day 7 of acute HDM-induced asthma to test their ability to reverse inflammatory pathology. The total number of infiltrating cells (A), the clinical score (see Table 1) (B), normalized cellular differentials from BALf harvests (C), and tissue pathology (D) by immunofluorescence staining for EpCAM (green) and MPO (red) from representative sections of pulmonary tissue are shown. * = p0.05. P value calculated from an unpaired Student’s T-Test. Error bars show mean with SEM. n = 6 to 14 individual mice total per group, across two asthma trials, as indicated on the White Blood Cell counts in panel C.