Endothelium-dependent and -independent aortic vascular relaxation in SED and EX mice.

A. Phenylephrine (PE)-mediated vascular contraction in aortic rings from SED and EX mice was expressed as a percentage maximum response to KPSS (n = 8 per group). B. Acetylcholine (ACh)-mediated endothelium-dependent relaxation in the aortic rings from SED and EX mice was expressed as a percentage relaxation of the pre-contraction elicited by PE EC80 (n = 8 per group). C. Sodium nitroprusside (SNP)-mediated endothelium-independent relaxation in the aortic rings from SED and EX mice was expressed as a percentage relaxation of the pre-contraction elicited by PE EC80 (n = 8 per group).