The effect of lamotrigine (LTG) to reverse the action of ivabradine (IVA) on the carrageenan-induced 50% paw withdrawal threshold (pain threshold) in rats.
- Saki Miyake (6733787)
- Hitoshi Higuchi (248619)
- Yuka Honda-Wakasugi (6733790)
- Maki Fujimoto (6733793)
- Hotaka Kawai (5840369)
- Hitoshi Nagatsuka (2578282)
- Shigeru Maeda (6733796)
- Takuya Miyawaki (3560828)
Publication date
May 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
Carrageenan at 1% was subcutaneously injected into the hindpaw, causing acute inflammation. IVA at 20 μM and/or LTG at 10 μM was injected into the hindpaw combined with carrageenan. (A) The time-course of the pain threshold until 8 hours after the injection of test solutions (CA: only carrageenan; CA + IVA20: carrageenan + IVA at 20 μM; CA + IVA20 + LTG: carrageenan + IVA at 20 μM + LTG at 10 μM; CA + LTG: carrageenan + LTG at 10 μM). (B) The pain threshold 2 hours after the injection of test solutions. **P< 0.01, ****P< 0.0001 compared with CA. # P< 0.05 compared with CA + IVA20. Data represent the mean ± SD (n = 6 for each).</p
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