The Influence of Sodium Fluoride upon the Composition of Tibiae of Rats Partially Recovering from Rickets

McClure (1) has recently called attention to the need for additional information dealing with the localization of fluorine in teeth and bones and with associative factors invoked in its absorption and metabolism. The work of Roholm (2) and Shortt (3) with the human being appeared to support this viewpoint strongly. Roholm (2) found that fluoride may cause either osteomalacia or osteosclerosis and that storage of fluorine in the bodies of female workers in the cryolite industry in Denmark was sometimes sufficiently great that, even after they left the factory, enough fluorine to cause tooth damage was secreted in their milk. Shortt (3) et al. found ostcosclerosis associated with 30 to 45 years residence in a mottled enamel area in India