The glycosylation of nucleocytoplasmic proteins by O-linked N-acetylglucosamine (O-GlcNAc) is important for regulation of protein function and cellular signaling. Addition of GlcNAc monosaccharide unit to target proteins requires the enzyme O-GlcNAc transferase (OGT), and removal of O-GlcNAc depends on the enzyme O-GlcNAcase (OGA). Previous works have shown that OGA inhibitors and enhancers of autophagy both reduced cognitive impairment as well as Aβ and tau aggregation in Alzheimer\u27s disease (AD) mouse models. Here, it was shown that OGA inhibition enhanced autophagy in neuro-2a cells and AD mouse brain through an mTOR independent pathway. These data suggest that OGA inhibition provides neuroprotection by promoting autophagy dependent c...
(Background) Amyloid plaques and neurofibrillary tangles (NFTs) are the defining pathological hallma...
The addn. of a single O-linked N-Acetylglucosamine (O-GlcNAc) sugar onto proteins is a ubiquitous an...
Alzheimer’s disease (AD) is the most common cause of progressive dementia in the elderly. It is char...
The glycosylation of nucleocytoplasmic proteins with O-linked <i>N</i>-acetylglucosamine residues (O...
The glycosylation of nucleocytoplasmic proteins with O-linked N-acetylglucosamine residues (O-GlcNAc...
Abnormal hyperphosphorylation of microtubule-associated protein tau plays a crucial role in neurodeg...
Abstract Background Hyperphosphorylation of microtubule-associated protein tau is a distinct feature...
Protein O-GlcNAcylation is a nutrient-related post-translational modification that, since its discov...
Abnormal hyperphosphorylation of microtubule-associated protein tau plays a crucial role in neurodeg...
Alzheimer disease (AD) is a growing problem for aging populations worldwide. Despite significant eff...
Abstract Post-translational modification on protein Ser/Thr residues by O-linked attachment of ß-N-a...
The O-linked addition of β-N-acetylglucosamine to proteins (O-GlcNAc) is a form of intracellular gly...
Background Amyloid plaques and neurofibrillary tangles (NFTs) are the defining pathological hallmark...
The O-GlcNAc post-translational modification involves the attachment of single N-acetyl-D-glucosamin...
Abnormal phosphorylation of tau has been considered as a key pathogenic mechanism inducing tau aggre...
(Background) Amyloid plaques and neurofibrillary tangles (NFTs) are the defining pathological hallma...
The addn. of a single O-linked N-Acetylglucosamine (O-GlcNAc) sugar onto proteins is a ubiquitous an...
Alzheimer’s disease (AD) is the most common cause of progressive dementia in the elderly. It is char...
The glycosylation of nucleocytoplasmic proteins with O-linked <i>N</i>-acetylglucosamine residues (O...
The glycosylation of nucleocytoplasmic proteins with O-linked N-acetylglucosamine residues (O-GlcNAc...
Abnormal hyperphosphorylation of microtubule-associated protein tau plays a crucial role in neurodeg...
Abstract Background Hyperphosphorylation of microtubule-associated protein tau is a distinct feature...
Protein O-GlcNAcylation is a nutrient-related post-translational modification that, since its discov...
Abnormal hyperphosphorylation of microtubule-associated protein tau plays a crucial role in neurodeg...
Alzheimer disease (AD) is a growing problem for aging populations worldwide. Despite significant eff...
Abstract Post-translational modification on protein Ser/Thr residues by O-linked attachment of ß-N-a...
The O-linked addition of β-N-acetylglucosamine to proteins (O-GlcNAc) is a form of intracellular gly...
Background Amyloid plaques and neurofibrillary tangles (NFTs) are the defining pathological hallmark...
The O-GlcNAc post-translational modification involves the attachment of single N-acetyl-D-glucosamin...
Abnormal phosphorylation of tau has been considered as a key pathogenic mechanism inducing tau aggre...
(Background) Amyloid plaques and neurofibrillary tangles (NFTs) are the defining pathological hallma...
The addn. of a single O-linked N-Acetylglucosamine (O-GlcNAc) sugar onto proteins is a ubiquitous an...
Alzheimer’s disease (AD) is the most common cause of progressive dementia in the elderly. It is char...