Acute bronchodilator responses decline progressively over 4 years in patients with moderate to very severe COPD.

We previously reported a progressive decline in absolute responses of FEV1 and FVC to a near-maximal dose of 2 different short-acting bronchodilators over 4 years. Since varying host factors and the method of expressing the response may impact the time trend of acute bronchodilator responses, we now examined the potential influence of salient host characteristics on changes in bronchodilator responses over time expressed in different ways.This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's website