Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.
- Bonifacio, E.
- Beyerlein, A.
- Hippich, M.
- Winkler, C.
- Vehik, K.
- Weedon, M. N.
- Laimighofer, M.
- Hattersley, Andrew T.
- Krumsiek, J.
- Frohnert, B. I.
- Steck, A. K.
- Hagopian, W. A.
- Krischer, J. P.
- Lernmark, Å.
- Rewers, M. J.
- She, J-X
- Toppari, J.
- Akolkar, B.
- Oram, Richard A.
- Rich, S. S.
- Ziegler, A-G
DOIAbstract
Around 0.3% of newborns will develop autoimmunity to pancreatic beta cells in childhood and subsequently develop type 1 diabetes before adulthood. Primary prevention of type 1 diabetes will require early intervention in genetically at-risk infants. The objective of this study was to determine to what extent genetic scores (two previous genetic scores and a merged genetic score) can improve the prediction of type 1 diabetes.This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site
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