A type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes.
- Johnson, M. B.
- Patel, K. A.
- De Franco, E.
- Houghton, Jayne A. L.
- McDonald, Timothy J.
- Ellard, Sian
- Flanagan, S. E.
- Hattersley, Andrew T.
DOIAbstract
Identifying individuals suitable for monogenic autoimmunity testing and gene discovery studies is challenging: early-onset type 1 diabetes mellitus can cluster with additional autoimmune diseases due to shared polygenic risk and islet- and other organ-specific autoantibodies are present in both monogenic and polygenic aetiologies. We aimed to assess whether a type 1 diabetes genetic risk score (GRS) could identify monogenic autoimmune diabetes and be useful to prioritise individuals for gene discovery studies
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