Rapid Down-Regulation of Glucocorticoid Gene Expression in the Dentate Gyrus after Acute Stress in vivo: Role of DNA Methylation and microRNA Activity.
- Mifsud, K. R.
- Saunderson, E. A.
- Spiers, H.
- Carter, S. D.
- Trollope, A. F.
- Mill, Jonathan
- Reul, J. M H M
DOIAbstract
Although glucocorticoid receptors (GRs) in the hippocampus play a vital role in the regulation of physiological and behavioural responses to stress, the regulation of receptor expression remains unclear. This work investigates the molecular mechanisms underpinning stress-induced changes in hippocampal GR mRNA levels in vivo
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