Genetic Variation at 16q24.2 is associated with small vessel stroke.
- Traylor, M.
- Malik, R.
- Nalls, M. A.
- Cotlarciuc, I.
- Radmanesh, F.
- Thorleifsson, G.
- Hanscombe, K. B.
- Langefeld, C.
- Saleheen, D.
- Rost, N. S.
- Yet, I.
- Spector, T. D.
- Bell, J. T.
- Hannon, E.
- Mill, Jonathan
- Chauhan, G.
- Debette, S.
- Bis, J.C.
- Longstreth, W. T.
- Ikram, M. A.
- Launer, L. J.
- Seshadri, S.
- Jimenez-Conde, J.
- Cole, J. W.
- Schmidt, R.
- Słowik, A.
- Lemmens, R.
- Lindgren, A.
- Melander, O.
- Grewal, R. P.
- Sacco, R. L.
- Rundek, T.
- Rexrode, K.
- Arnett, D. K.
- Johnson, J. A.
- Benavente, O. R.
- Wasssertheil-Smoller, S.
- Lee, J-M
- Pulit, S. L.
- Wong, Q.
- Rich, S. S.
- de Bakker, P. I. W.
- McArdle, P. F.
- Woo, D.
- Anderson, C. D.
- Xu, H.
- Heitsch, L.
- Fornage, M.
- Jern, C.
- Stefansson, K.
- Thorsteinsdottir, U.
- Gretarsdottir, S.
- Lewis, C. M.
- Sharma, P.
- Sudlow, C. L. M.
- Rothwell, P. M.
- Boncoraglio, G. B.
- Thijs, V.
- Levi, C.
- Meschia, J. F.
- Rosand, J.
- Kittner, S. J.
- Mitchell, B. D.
- Dichgans, M.
- Worrall, B. B.
- Markus, H. S.
DOIAbstract
Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises a quarter of all ischaemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neurological traits have shown younger onset cases have an increased genetic burden. We leveraged this increased genetic burden by performing an age-at-onset informed GWAS meta-analysis, including a large younger onset SVS population, to identify novel associations with stroke
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