Innovatives liposomes for overcoming biological barriers

In this thesis work were prepared and characterized liposomes and liposomes modified with a coating of chitosan called chitosomes. Through these structures were conveyed drugs of natural origin with anti-inflammatory and antioxidant properties: quercetin,phycocyanin and curcumin. The liposomes loading quercetin and phycocyanin are designed for a topical application and were tested on new born pig skin. Liposomes and chitosomes loading curcumin are designed for pulmonary delivery as a cure for cystic fibrosis. In this case, has been tested the toxicity of the system using a model of lung tissue using Calu-3 cells. The drug delivery via liposomes and chitosomes improves the retention time of the drug and increases its stability. Studies continue with biocompatibility and in vivo tests