Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.
- Georgiadis, Markos-Orestis
- Kourbeli, Violeta
- Ioannidou, Vaya
- Karakitsios, Evangelos
- Papanastasiou, Ioannis
- Tsotinis, Andrew
- Komiotis, Dimitri
- Vocat, Anthony
- Cole, Stewart T
- Taylor, Martin C
- Kelly, John M
DOIAbstract
In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpiperazine derivative Ia is the most potent against T. brucei compound, whilst its hexylamine congener IIf exhibits a significant antimycobacterial activity
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