Multiscale study of the hepatic volume evolution after major hepatectomie in a porcine model

Ce travail si concerne l`etude d`evolution du volume du fois apres l`hepatectomie majeure chez les porcs.Le planning se compose des imagairies sequentielle avant et apres le chirurgie, dans laquelle ablation d`une parite precis du fois est effectue. En suite, on etudie l`evolution de volume du fois et les facteures hemodynamic qui ont d`influence sur cet evolution.The aim of this project is double. Firstly, relationships between liver function, blood flows and architecture along with liver volume after major hepatectomy will be carefully analyzed by combining experiments and modeling on multiple levels and scales. These results will be used by mathematicians to develop an alternative evaluation procedure based on innovative tools in order to improve identification of possible or likely post-operative liver failure as early as possible. In this way a critical liver function decrease can be duly treated. Preliminary studies in pigs indicate that patients in which liver failure is likely to occur, may significantly benefit from an implantable surgical device capable of modulating the diameter of the portal vein hence controlling the portal venous pressure into the liver