International audience5-Hydroxytryptamine subtype-4 (5-HT(4)) receptors have stimulated considerable interest amongst scientists and clinicians owing to their importance in neurophysiology and potential as therapeutic targets. A comparative analysis of hierarchical methods applied to data from one thousand 5-HT(4) receptor-ligand binding interactions was carried out. The chemical structures were described as chemical and pharmacophore fingerprints. The definitions of indices, related to the quality of the hierarchies in being able to distinguish between active and inactive compounds, revealed two interesting hierarchies with the Unity (1 active cluster) and pharmacophore fingerprints (4 active clusters). The results of this study also showe...
The study of the interaction between a ligand and its receptor requires to know the structure of the...
The need to develop selective compounds for 5-HT receptors requires further elucidation of structure...
Antidepressants have different receptor binding profiles, which are related to therapeutic action an...
The 5-hydroxytryptamine receptor 6 (5-HT6) has gained attention as a target for developing therapeut...
Upon binding to a receptor, agonists and antagonists can induce distinct biological functions and th...
Upon binding to a receptor, agonists and antagonists can induce distinct biological functions and th...
International audienceThis article reviews the medicinal implications of 5-HT(4)R in the peripheral ...
ABSTRACT: The 5-hydroxytryptamine 1A (5-HT1A) serotonin receptor has been an attractive target for t...
All tested compounds show agonistic activity onserotonin5-HT2areceptors, which activation causes neu...
This study explores a new approach to pharmacophore screening involving the use of an optimized line...
The pharmacologically characterized receptor subtype of the serotonin family, the 5HT1A receptor is ...
Creation of a statistically reliable 3D-QSAR (Quantitative Structure Activity Relationships) model e...
The human histamine H4 receptor (hH4R), a member of the G-protein coupled receptors (GPCR) family, i...
A three-dimensional quantitative structure - activity relationship study (3D QSAR) has been successf...
The identification of protein function based on biological information is an area of intense researc...
The study of the interaction between a ligand and its receptor requires to know the structure of the...
The need to develop selective compounds for 5-HT receptors requires further elucidation of structure...
Antidepressants have different receptor binding profiles, which are related to therapeutic action an...
The 5-hydroxytryptamine receptor 6 (5-HT6) has gained attention as a target for developing therapeut...
Upon binding to a receptor, agonists and antagonists can induce distinct biological functions and th...
Upon binding to a receptor, agonists and antagonists can induce distinct biological functions and th...
International audienceThis article reviews the medicinal implications of 5-HT(4)R in the peripheral ...
ABSTRACT: The 5-hydroxytryptamine 1A (5-HT1A) serotonin receptor has been an attractive target for t...
All tested compounds show agonistic activity onserotonin5-HT2areceptors, which activation causes neu...
This study explores a new approach to pharmacophore screening involving the use of an optimized line...
The pharmacologically characterized receptor subtype of the serotonin family, the 5HT1A receptor is ...
Creation of a statistically reliable 3D-QSAR (Quantitative Structure Activity Relationships) model e...
The human histamine H4 receptor (hH4R), a member of the G-protein coupled receptors (GPCR) family, i...
A three-dimensional quantitative structure - activity relationship study (3D QSAR) has been successf...
The identification of protein function based on biological information is an area of intense researc...
The study of the interaction between a ligand and its receptor requires to know the structure of the...
The need to develop selective compounds for 5-HT receptors requires further elucidation of structure...
Antidepressants have different receptor binding profiles, which are related to therapeutic action an...