Plants respond to annual climate conditions, the grapevine being particularly sensitive to temperature and water regime. The variation in length of physiological states such as ripening, and the final composition of grapes, show a crop response to the weather. The aim of this study was to analyze the evolution of the bio-indices and determine the cv. Tannat plant responses to climate variability observed in a number of years in southern Uruguay. In a period of sixteen years, we assessed climate conditions through bio-indices (Index of Hulgin Heliothermic IH, Freshness Index of Nights IF, and IS Drought Index), considering temperature, precipitation and potential evapotranspiration during growing season. We analyzed dates of veraison and har...