La Trisomie 21 ou Syndrome de Down, est due à la présence surnuméraire du chromosome 21 humain (Hsa21), le surdosage génétique qui en résulte provoque différents phénotypes. Cette pathologie est la première cause de retard mental. Notre étude vise à savoir si l’aneuploïdie d’un intervalle génétique, encore non étudié, entraîne des modifications dans la mise en place des processus à l’origine des facultés cognitives. Cet intervalle, entre les gènes Cstb et Prmt2 est porté par le chromosome murin 10 (MMU10) au sein d’une portion homologue à la partie télomérique du Hsa21. Pour cela de nouveaux modèles murins ont été créés, Ms4Yah est monosomique et Ts3Yah est trisomique pour cet intervalle. Le but est donc de caractériser les conséquences de ...
Down Syndrome (DS) is the most frequent intellectual disability (ID) syndrome and is associated with...
Les variations du nombre de copies (CNVs) incluent les délétions et les duplications de régions chro...
Mental retardation in Down syndrome (DS), the most frequent trisomy in humans, varies from moderate ...
Trisomy 21 or Down syndrome is due to a third copy of human chromosome 21 (Hsa21) in the genome, thi...
Le Syndrome de Down ou trisomie 21 est une maladie congénitale complexe qui affecte le développement...
The Down syndrome (DS), or Trisomy21, is the most frequent aneuploidy in human. The genomic disorder...
International audienceWe hypothesize that the trisomy 21 (Down syndrome) is the additive and interac...
La trisomie 21 est la première cause de retard mental, phénotype majeur de la maladie. Elle est due ...
Down syndrome results from triplication of human chromosome 21. The distal end of mouse chromosome 1...
Copy number variations (CNVs) include deletions and duplications of chromosomal regions ranging in s...
Down syndrome (DS), trisomy for chromosome 21, is the most common genetic cause of intellectual disa...
Down syndrome (DS) results from an additional copy of human chromosome 21 (Hsa21). It is a leading c...
<div><p>Down syndrome (DS), trisomy for chromosome 21, is the most common genetic cause of intellect...
International audienceDown syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). The un...
Aneuploidies are common chromosomal defects that result in growth and developmental deficits and hig...
Down Syndrome (DS) is the most frequent intellectual disability (ID) syndrome and is associated with...
Les variations du nombre de copies (CNVs) incluent les délétions et les duplications de régions chro...
Mental retardation in Down syndrome (DS), the most frequent trisomy in humans, varies from moderate ...
Trisomy 21 or Down syndrome is due to a third copy of human chromosome 21 (Hsa21) in the genome, thi...
Le Syndrome de Down ou trisomie 21 est une maladie congénitale complexe qui affecte le développement...
The Down syndrome (DS), or Trisomy21, is the most frequent aneuploidy in human. The genomic disorder...
International audienceWe hypothesize that the trisomy 21 (Down syndrome) is the additive and interac...
La trisomie 21 est la première cause de retard mental, phénotype majeur de la maladie. Elle est due ...
Down syndrome results from triplication of human chromosome 21. The distal end of mouse chromosome 1...
Copy number variations (CNVs) include deletions and duplications of chromosomal regions ranging in s...
Down syndrome (DS), trisomy for chromosome 21, is the most common genetic cause of intellectual disa...
Down syndrome (DS) results from an additional copy of human chromosome 21 (Hsa21). It is a leading c...
<div><p>Down syndrome (DS), trisomy for chromosome 21, is the most common genetic cause of intellect...
International audienceDown syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). The un...
Aneuploidies are common chromosomal defects that result in growth and developmental deficits and hig...
Down Syndrome (DS) is the most frequent intellectual disability (ID) syndrome and is associated with...
Les variations du nombre de copies (CNVs) incluent les délétions et les duplications de régions chro...
Mental retardation in Down syndrome (DS), the most frequent trisomy in humans, varies from moderate ...