International audienceOxidative stress, associated with various neurodegenerative diseases, promotes ROS generation, impairs cellular antioxidant defenses, and finally, triggers both neurons and astroglial cell death by apoptosis. Astrocytes specifically synthesize and release endozepines, a family of regulatory peptides, including the octadecaneuropeptide (ODN). We have previously reported that ODN acts as a potent neuroprotective agent that prevents 6-OHDA-induced apoptotic neuronal death. The purpose of the present study was to investigate the potential glioprotective effect of ODN on 6-OHDA-induced oxidative stress and cell death in cultured rat astrocytes. Incubation of astrocytes with graded concentrations of ODN (10-14 to 10-8 M) inh...
International audienceOxidative stress, associated with a variety of disorders including neurodegene...
Recent evidence shows that biochemical mechanisms that occur in response to traumatic brain injury c...
<p>(A) Cultured astrocytes were pre-incubated for 10 min in the absence or presence of graded concen...
International audienceOxidative stress, associated with a variety of disorders including neurodegene...
International audienceOxidative stress, resulting from accumulation of reactive oxygen species (ROS)...
Astroglial cells possess an array of cellular defense systems, including superoxide dismutase (SOD) ...
International audienceOxidative stress, induced by various neurodegenerative diseases, initiates a c...
International audienceAstroglial cells are important actors in the defense of brain against oxidativ...
Astrocytes synthesize and release endozepines, a family of regulatory peptides, including the octade...
International audienceAstrocytes synthesize and release endozepines, a family of regulatory peptides...
International audienceThe term endozepines designates a family of astroglia-secreted proteins includ...
International audienceParkinson's disease (PD) is a neurodegenerative disorder characterized by a pr...
International audienceAstroglial cells possess an array of cellular defense mechanisms, including su...
International audienceNeurodegenerative diseases are characterized by oxidative stress, mitochondria...
Parkinson's disease (PD) is a neurodegenerative disorder characterized by a progressive loss of loss...
International audienceOxidative stress, associated with a variety of disorders including neurodegene...
Recent evidence shows that biochemical mechanisms that occur in response to traumatic brain injury c...
<p>(A) Cultured astrocytes were pre-incubated for 10 min in the absence or presence of graded concen...
International audienceOxidative stress, associated with a variety of disorders including neurodegene...
International audienceOxidative stress, resulting from accumulation of reactive oxygen species (ROS)...
Astroglial cells possess an array of cellular defense systems, including superoxide dismutase (SOD) ...
International audienceOxidative stress, induced by various neurodegenerative diseases, initiates a c...
International audienceAstroglial cells are important actors in the defense of brain against oxidativ...
Astrocytes synthesize and release endozepines, a family of regulatory peptides, including the octade...
International audienceAstrocytes synthesize and release endozepines, a family of regulatory peptides...
International audienceThe term endozepines designates a family of astroglia-secreted proteins includ...
International audienceParkinson's disease (PD) is a neurodegenerative disorder characterized by a pr...
International audienceAstroglial cells possess an array of cellular defense mechanisms, including su...
International audienceNeurodegenerative diseases are characterized by oxidative stress, mitochondria...
Parkinson's disease (PD) is a neurodegenerative disorder characterized by a progressive loss of loss...
International audienceOxidative stress, associated with a variety of disorders including neurodegene...
Recent evidence shows that biochemical mechanisms that occur in response to traumatic brain injury c...
<p>(A) Cultured astrocytes were pre-incubated for 10 min in the absence or presence of graded concen...