Malgré les récentes avancées réalisées dans le traitement du cancer du côlon, la résistance des tumeurs est une cause fréquente de l'échec des chimiothérapies. Cette thèse a pour objectif d'identifier les mécanismes moléculaires impliqués dans la résistance à l'Irinotécan, un agent couramment utilisé dans le traitement des cancers colorectaux. Nous avons montré l'implication de la MAPK p38 dans la résistance à l'Irinotécan et en particulier avons démontré que les isoformes α et β étaient impliquées dans cette résistance. De plus, nous avons corrélé la faible phosphorylation de p38 dans des tumeurs coliques primaires de patient sensibles au traitement à l'Irinotécan par rapport aux patients non répondeurs. Dans la suite du projet nous avons ...
Autophagy is a vacuolar process leading to the degradation of long-lived proteins and cytoplasmic or...
PROBLEM: Resistance to chemotherapy remains a major clinical issue in the treatment of colorectal ca...
p38α (Mapk14) is a member of the MAP kinase family and can be activated by environmental stress sign...
International audienceDespite recent advances in the treatment of colon cancer, tumor resistance is ...
International audienceDespite recent advances in the treatment of colon cancer, tumor resistance is ...
L’irinotecan est un agent anticancéreux majeur utilisé dans le traitement du cancer du côlon où il a...
Colorectal cancer (CRC) remains one of the most common malignancies in the world. Although surgical ...
International audienceRecently we have shown that the mitogen-activated protein kinase (MAPK) MAPK14...
Acquired drug resistance to the chemotherapeutic drug irinotecan (the active metabolite of which is ...
BACKGROUND & AIMS: Stem cells of normal tissues have resistance mechanisms that allow them to surviv...
Le cancer colorectal est un cancer majeur en termes de fréquence et de mortalité. Il s’agit de la de...
L irinotecan est un agent anticancéreux majeur utilisé dans le traitement du cancer du côlon où il a...
PROBLEM: Resistance to chemotherapy remains a major clinical issue in the treatment of colorectal ca...
Treatment with pharmacological drugs for colorectal cancer (CRC) remains unsatisfactory. A major cau...
Comprehensive genomic profiling is expected to revolutionize cancer therapy. Recent advances in DNA ...
Autophagy is a vacuolar process leading to the degradation of long-lived proteins and cytoplasmic or...
PROBLEM: Resistance to chemotherapy remains a major clinical issue in the treatment of colorectal ca...
p38α (Mapk14) is a member of the MAP kinase family and can be activated by environmental stress sign...
International audienceDespite recent advances in the treatment of colon cancer, tumor resistance is ...
International audienceDespite recent advances in the treatment of colon cancer, tumor resistance is ...
L’irinotecan est un agent anticancéreux majeur utilisé dans le traitement du cancer du côlon où il a...
Colorectal cancer (CRC) remains one of the most common malignancies in the world. Although surgical ...
International audienceRecently we have shown that the mitogen-activated protein kinase (MAPK) MAPK14...
Acquired drug resistance to the chemotherapeutic drug irinotecan (the active metabolite of which is ...
BACKGROUND & AIMS: Stem cells of normal tissues have resistance mechanisms that allow them to surviv...
Le cancer colorectal est un cancer majeur en termes de fréquence et de mortalité. Il s’agit de la de...
L irinotecan est un agent anticancéreux majeur utilisé dans le traitement du cancer du côlon où il a...
PROBLEM: Resistance to chemotherapy remains a major clinical issue in the treatment of colorectal ca...
Treatment with pharmacological drugs for colorectal cancer (CRC) remains unsatisfactory. A major cau...
Comprehensive genomic profiling is expected to revolutionize cancer therapy. Recent advances in DNA ...
Autophagy is a vacuolar process leading to the degradation of long-lived proteins and cytoplasmic or...
PROBLEM: Resistance to chemotherapy remains a major clinical issue in the treatment of colorectal ca...
p38α (Mapk14) is a member of the MAP kinase family and can be activated by environmental stress sign...