Clinical feasibility of Gd-EOB-DTPA-enhanced MR imaging for assessing liver function: validation with ICG tests and parenchymal cell volume

Objective: Using Gd-EOB-DTPA-enhanced MRI to assess liver function and validate with indocyanine green (ICG) tests and parenchymal cell volume (PCV). ;Methods: Nineteen patients scheduled for operation were enrolled. Functional liver volume (FLV) was computed from 20 min post-contrast images. ICG retention was measured in serum 15 min after injection. The histological PCV was determined from resected liver specimen. ;Results: FLV showed significantly correlated with ICG retention (ICG-R15: r=-0.47, P=.042) and PCV (r=0.814, P<.001). ;Conclusions: Gd-EOB-DTPA-enhanced MRI is clinically feasible for quantifying liver function. (C) 2016 Elsevier Inc. All rights reserved