The chaotic spatial disarray due to extracellular matrix expansion disrupts cardiomyocytes interaction and causes arrhythmia. We hypothesized that disordered nanopeptide scaffolds can mimic the chaotic spatial disarray related to cardiac fibrosis and have arrhythmogenic effects on cardiomyocytes. Primary mouse cardiomyocytes were cultured in 2D traditional and 3D nanopeptide hydrogel scaffold systems. Cardiomyocytes in 3D scaffolds showed irregular spontaneous contractile activity as compared with 2D culture controls. Calcium fluorimetric imaging revealed that basal intracellular calcium level increased 1.42-fold in cardiomyocytes cultured in the 3D scaffold, in vitro. The mRNA levels of sarcoplasmic reticulum calcium transport ATPase, ryan...
International audienceLimited data are available on the effects of stem cells in non-ischemic dilate...
Engineered heart tissue (EHT) has ample potential as a model for in vitro tissue modeling or tissue ...
A human in vitro cardiac tissue model would be a significant advancement for understanding, studying...
AbstractThe chaotic spatial disarray due to extracellular matrix expansion disrupts cardiomyocytes i...
Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) are widely suggested as a suit...
Current drug discovery is impeded by insufficient models that do not accurately recapitulate physiol...
Neonatal cardiomyocytes cultured on flat surfaces are commonly used as a model to study cardiac fail...
Activation of cardiac fibroblasts into myofibroblasts is considered to play an essential role in car...
Engineered cardiac tissue models become increasingly important for understanding normal and diseased...
Tissue engineering approaches are currently being investigated for the restoration of myocardial fun...
The heart possesses a complex three-dimensional (3D) laminar myofiber organization; however, because...
Toward engineering a cardiac patch, the objective of this work was to assess stem cell response to a...
Ex vivo cardiomyocytes production from pluripotent stem cells is highly attractive as a future clini...
In the past few years, microfluidic-based technology has developed microscale models recapitulating ...
In vitro cardiac modeling has taken great strides in the past decade. While most cell and engineere...
International audienceLimited data are available on the effects of stem cells in non-ischemic dilate...
Engineered heart tissue (EHT) has ample potential as a model for in vitro tissue modeling or tissue ...
A human in vitro cardiac tissue model would be a significant advancement for understanding, studying...
AbstractThe chaotic spatial disarray due to extracellular matrix expansion disrupts cardiomyocytes i...
Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) are widely suggested as a suit...
Current drug discovery is impeded by insufficient models that do not accurately recapitulate physiol...
Neonatal cardiomyocytes cultured on flat surfaces are commonly used as a model to study cardiac fail...
Activation of cardiac fibroblasts into myofibroblasts is considered to play an essential role in car...
Engineered cardiac tissue models become increasingly important for understanding normal and diseased...
Tissue engineering approaches are currently being investigated for the restoration of myocardial fun...
The heart possesses a complex three-dimensional (3D) laminar myofiber organization; however, because...
Toward engineering a cardiac patch, the objective of this work was to assess stem cell response to a...
Ex vivo cardiomyocytes production from pluripotent stem cells is highly attractive as a future clini...
In the past few years, microfluidic-based technology has developed microscale models recapitulating ...
In vitro cardiac modeling has taken great strides in the past decade. While most cell and engineere...
International audienceLimited data are available on the effects of stem cells in non-ischemic dilate...
Engineered heart tissue (EHT) has ample potential as a model for in vitro tissue modeling or tissue ...
A human in vitro cardiac tissue model would be a significant advancement for understanding, studying...