Acute kidney injury (AKI) is an important risk factor for incident chronic kidney disease (CKD). Clinical studies disclose that ensuing CKD progresses after functional recovery from AKI, but the underlying mechanisms remain illusive. Using a murine model representing AKI-CKD continuum, we show angiotensin II type 1a (AT1a) receptor signaling as one of the underlying mechanisms. Male adult CD-1 mice presented severe AKI with 20% mortality within 2 weeks after right nephrectomy and left renal ischemia-reperfusion injury. Despite functional recovery, focal tubular atrophy, interstitial cell infiltration and fibrosis, upregulation of genes encoding angiotensinogen and AT1a receptor were shown in kidneys 4 weeks after AKI. Thereafter mice manife...
Cardiovascular disease is dramatically increased across the entire spectrum of patients with chronic...
Background: Chronic renal failure (CRF) is associated with hypertension, proteinuria, loss of myogen...
Renin angiotensin system (RAS) plays a key role in the pathogenesis and progression of hypertension ...
Background/Aims: Contributions to the understanding of acute renal failure (ARF) pathogenesis have n...
Ischemic acute renal failure (ARF) is a highly complex disorder involving renal vasoconstriction, fi...
The role of the renin-angiotensin system in chronic kidney disease involves multiple peptides and re...
Ischemia/reperfusion (I/R) is a major cause of acute kidney injury. Several studies have shown that ...
Introduction: Chronic kidney disease (CKD) is a global health concern, but the current treatments on...
Fraune C, Lange S, Krebs C, Holzel A, Baucke J, Divac N, Schwedhelm E, Streichert T, Velden J, Garre...
Blood pressure and fluid regulation are kept constant through the interaction between heart and kidn...
Treatments that effectively prevent chronic kidney disease (CKD) when initiated early often yield di...
Fraune C, Lange S, Krebs C, Holzel A, Baucke J, Divac N, Schwedhelm E, Streichert T, Velden J, Garre...
The remnant kidney model in C57BL/6 mice does not develop progressive chronic kidney disease (CKD). ...
Suppression of the renin-angiotensin system during lactation causes irreversible renal structural ch...
Copyright © 2014 Hee-Seong Jang et al.This is an open access article distributed under the Creative ...
Cardiovascular disease is dramatically increased across the entire spectrum of patients with chronic...
Background: Chronic renal failure (CRF) is associated with hypertension, proteinuria, loss of myogen...
Renin angiotensin system (RAS) plays a key role in the pathogenesis and progression of hypertension ...
Background/Aims: Contributions to the understanding of acute renal failure (ARF) pathogenesis have n...
Ischemic acute renal failure (ARF) is a highly complex disorder involving renal vasoconstriction, fi...
The role of the renin-angiotensin system in chronic kidney disease involves multiple peptides and re...
Ischemia/reperfusion (I/R) is a major cause of acute kidney injury. Several studies have shown that ...
Introduction: Chronic kidney disease (CKD) is a global health concern, but the current treatments on...
Fraune C, Lange S, Krebs C, Holzel A, Baucke J, Divac N, Schwedhelm E, Streichert T, Velden J, Garre...
Blood pressure and fluid regulation are kept constant through the interaction between heart and kidn...
Treatments that effectively prevent chronic kidney disease (CKD) when initiated early often yield di...
Fraune C, Lange S, Krebs C, Holzel A, Baucke J, Divac N, Schwedhelm E, Streichert T, Velden J, Garre...
The remnant kidney model in C57BL/6 mice does not develop progressive chronic kidney disease (CKD). ...
Suppression of the renin-angiotensin system during lactation causes irreversible renal structural ch...
Copyright © 2014 Hee-Seong Jang et al.This is an open access article distributed under the Creative ...
Cardiovascular disease is dramatically increased across the entire spectrum of patients with chronic...
Background: Chronic renal failure (CRF) is associated with hypertension, proteinuria, loss of myogen...
Renin angiotensin system (RAS) plays a key role in the pathogenesis and progression of hypertension ...