The emphasis on periodontal regeneration has been shifted towards the harmonization of bioactive molecules and physiological phases during regeneration. This study investigated whether the combination and sequential-release of platelet-derived growth factor (PDGF, mitogen) and simvastatin (differentiation factor) facilitated periodontal regeneration. PDGF and simvastatin were encapsulated in double-walled poly-(D,L-lactide) and poly-(D,L-lactide-co-glycolide) (PDLLA-PLGA) microspheres using the co-axial electrohydrodynamic atomization technique. Critical-sized periodontal defects on rat maxillae were filled with microspheres encapsulating BSA-in-core-shell (BB), PDGF-in-shell (XP), simvastatin-in-core and BSA-in-shell (SB), simvastatin-in-c...
Alveolar bone loss as a result of periodontitis and physiological alveolar bone resorption following...
Clinical research has long been testing techniques of integrating biomaterials with many external fa...
Clinical research has long been testing techniques of integrating biomaterials with many external fa...
Objectives: Timely augmentation of the physiological events of dentoalveolar repair is a prerequisit...
Currently available clinical therapies are not capable to regenerate tissues that are lost by period...
Item does not contain fulltextCurrently available clinical therapies are not capable to regenerate t...
10.1002/jbm.a.34244Journal of Biomedical Materials Research - Part A100 A112970-2978JBMR
With currently available therapies, full regeneration of lost periodontal tissues after periodontiti...
Copyright © 2013 KaustubhThakare et al. This is an open access article distributed under the Creativ...
Platelet-derived growth factor-BB (PDGF-BB) was incorporated into porous poly (L-lactide) (PLLA) m...
Alveolar bone loss as a result of periodontitis and physiological alveolar bone resorption following...
Periodontal disease destroys supporting structures of teeth. However, tissue engineering strategies ...
Background—Cementum, a mineralized tissue lining the tooth root surface, is destroyed during the inf...
Destruction of tooth support due to the chronic inflammatory disease periodontitis is a major cause ...
Clinical research has long been testing techniques of integrating biomaterials with many external fa...
Alveolar bone loss as a result of periodontitis and physiological alveolar bone resorption following...
Clinical research has long been testing techniques of integrating biomaterials with many external fa...
Clinical research has long been testing techniques of integrating biomaterials with many external fa...
Objectives: Timely augmentation of the physiological events of dentoalveolar repair is a prerequisit...
Currently available clinical therapies are not capable to regenerate tissues that are lost by period...
Item does not contain fulltextCurrently available clinical therapies are not capable to regenerate t...
10.1002/jbm.a.34244Journal of Biomedical Materials Research - Part A100 A112970-2978JBMR
With currently available therapies, full regeneration of lost periodontal tissues after periodontiti...
Copyright © 2013 KaustubhThakare et al. This is an open access article distributed under the Creativ...
Platelet-derived growth factor-BB (PDGF-BB) was incorporated into porous poly (L-lactide) (PLLA) m...
Alveolar bone loss as a result of periodontitis and physiological alveolar bone resorption following...
Periodontal disease destroys supporting structures of teeth. However, tissue engineering strategies ...
Background—Cementum, a mineralized tissue lining the tooth root surface, is destroyed during the inf...
Destruction of tooth support due to the chronic inflammatory disease periodontitis is a major cause ...
Clinical research has long been testing techniques of integrating biomaterials with many external fa...
Alveolar bone loss as a result of periodontitis and physiological alveolar bone resorption following...
Clinical research has long been testing techniques of integrating biomaterials with many external fa...
Clinical research has long been testing techniques of integrating biomaterials with many external fa...