Add to ORKGTwo new morphinane alkaloids, 1-hydroxy-10-oxo-sinomenine 1 and 4,5-epoxy -14-hydroxy sinomenine N-oxide 2, have been isolated from the stems of Sinomenium acutum. Their structures were established by various spectral analyses, especially 2D NMR experiments. The structure of 2 was confirmed by single crystal X-ray diffraction. The absolute configurations of 1 and 2 were deduced by comparison of CD spectra with the known alkaloid sinomenine 3. Compound 1 was tested for DPPH inhibition and gave IC50 of 27.9M. Compound 2 was tested for neuroprotective effect and showed significant activity against -amyloid25-35-induced oxidative injury *P0.05 at 10M in PC-12 cells
<p>A phytochemical study of the root barks of <i>Aconitum sinchiangense</i> W. T. Wang, a traditiona...
Two new morphinandienone alkaloids, trans B/C-4-hydroxy-3,6-dimethoxy-5,6-didehydromorphinan-7-one (...
R factor = 0.070; wR factor = 0.208; data-to-parameter ratio = 7.6. The title compound, C20H25NO4, w...
is a deciduous shrub grown in Asia, particularly in Japan, China, and Korea. The stems and roots of ...
Sinomenine is a morphinan alkaloid with a variety of biological activities. Its derivatives have sho...
The root and stem decoctions of Sinomenium acutum Rehd. et Wils. (formerly Sinomenium diversifolius ...
Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation...
The characterization of alkaloids is challenging because of the diversity of structures and the comp...
A new morphinan alkaloid (6S, 9S, 13 R, 14S)-6-O-acetyl-7,8-Didehydro-4-hydroxy-3,7-dimethoxymorphin...
Sinomenine is the main component of the vine Sinomenium acutum. It was first isolated in the early 1...
Sinomenine is extracted from Sinomenii caulis (a traditional Chinese medicine), and it is used as th...
Two new N-oxide alkaloids with pyrrolo[1,2-α]azepine skeleton, namely isoneostemocochinine-N-oxide (...
Purified from the roots of the plant Sinomenium acutum, sinomenine is traditionally used in China an...
Three new proaporphine alkaloids, cissamaline (4), cissamanine (5), and cissamdine (6), along with t...
The first chemical study on the stems and leaves of Daphniphyllum yunnanense led to the isolation of...
<p>A phytochemical study of the root barks of <i>Aconitum sinchiangense</i> W. T. Wang, a traditiona...
Two new morphinandienone alkaloids, trans B/C-4-hydroxy-3,6-dimethoxy-5,6-didehydromorphinan-7-one (...
R factor = 0.070; wR factor = 0.208; data-to-parameter ratio = 7.6. The title compound, C20H25NO4, w...
is a deciduous shrub grown in Asia, particularly in Japan, China, and Korea. The stems and roots of ...
Sinomenine is a morphinan alkaloid with a variety of biological activities. Its derivatives have sho...
The root and stem decoctions of Sinomenium acutum Rehd. et Wils. (formerly Sinomenium diversifolius ...
Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation...
The characterization of alkaloids is challenging because of the diversity of structures and the comp...
A new morphinan alkaloid (6S, 9S, 13 R, 14S)-6-O-acetyl-7,8-Didehydro-4-hydroxy-3,7-dimethoxymorphin...
Sinomenine is the main component of the vine Sinomenium acutum. It was first isolated in the early 1...
Sinomenine is extracted from Sinomenii caulis (a traditional Chinese medicine), and it is used as th...
Two new N-oxide alkaloids with pyrrolo[1,2-α]azepine skeleton, namely isoneostemocochinine-N-oxide (...
Purified from the roots of the plant Sinomenium acutum, sinomenine is traditionally used in China an...
Three new proaporphine alkaloids, cissamaline (4), cissamanine (5), and cissamdine (6), along with t...
The first chemical study on the stems and leaves of Daphniphyllum yunnanense led to the isolation of...
<p>A phytochemical study of the root barks of <i>Aconitum sinchiangense</i> W. T. Wang, a traditiona...
Two new morphinandienone alkaloids, trans B/C-4-hydroxy-3,6-dimethoxy-5,6-didehydromorphinan-7-one (...
R factor = 0.070; wR factor = 0.208; data-to-parameter ratio = 7.6. The title compound, C20H25NO4, w...