A fungal immunomodulatory protein (FIP-gts) was purified from Ganoderma tsugae. Recombinant FIP-gts was expressed as glutathione S-transferase fusion protein in E. coli. In this study, recombinant FIP-gts promoted cell cycle progression from G0/G1 to S phase and signaling pathways were investigated in human peripheral mononuclear cells (HPBMCs) by PI staining and flow cytometry. FIP-gts significantly induced cytokine interferon- gamma (IFN-gamma) expression. Pre-treatment of cells with phosphatidylinositol 3-kinase ( PI 3-kinase) inhibitor LY294002 abolished FIP-gts, induced increase in S phase, and inhibited IFN-gamma secretion. Akt, a downstream effector of PI 3-kinase was phosphorylated and activated by FIP-gts. Results show that FIP-gts...
Immunomodulation by fungal compounds can be determined by the capacity of the compounds to influence...
Ganoderma lucidum is a medicinal mushroom in China and other Asian countries. The polysaccharide fro...
Differentiation therapy by induction of tumor cells is an important method in the treatment of hemat...
FIP-fve is a fungal immunomodulatory protein purified from Flammulina velutipes, an edible golden ne...
Telomerase expression is the hallmark of tumor cells, and activation of this ribonucleoprotein compl...
Fip-gts, an immunomodulatory protein purified from Ganoderma tsugae, has been reported to possess th...
Abstract Background More than a dozen of fungal immunomodulatory proteins (FIPs) have been identifie...
[[abstract]]Ganoderma, also known as Lingzhi or Reishi, has been used for medicinal purposes in Asia...
Medicinal mushrooms have been traditionally used as food nutrient supplements in China for thousands...
Microglia polarization of classical activation state is crucial to the induction of neuroinflammatio...
Ganoderma lucidum polysaccharides (Gl-PS) have shown a variety of immune modulating effects. Culture...
Ganoderma lucidum, a fungus native to China, has been widely used to promote health and longevity in...
1 The polysaccharide from Ganoderma lucidum (PS-G) has been reported to enhance immune responses and...
Ganoderma formosanum (GF) is a medicinal mushroom endemic to Taiwan. Previous research established t...
Some cytokines, such as interleukin-2 (IL-2), interferon-gamma (IFN-gamma) and tumor necrosis factor...
Immunomodulation by fungal compounds can be determined by the capacity of the compounds to influence...
Ganoderma lucidum is a medicinal mushroom in China and other Asian countries. The polysaccharide fro...
Differentiation therapy by induction of tumor cells is an important method in the treatment of hemat...
FIP-fve is a fungal immunomodulatory protein purified from Flammulina velutipes, an edible golden ne...
Telomerase expression is the hallmark of tumor cells, and activation of this ribonucleoprotein compl...
Fip-gts, an immunomodulatory protein purified from Ganoderma tsugae, has been reported to possess th...
Abstract Background More than a dozen of fungal immunomodulatory proteins (FIPs) have been identifie...
[[abstract]]Ganoderma, also known as Lingzhi or Reishi, has been used for medicinal purposes in Asia...
Medicinal mushrooms have been traditionally used as food nutrient supplements in China for thousands...
Microglia polarization of classical activation state is crucial to the induction of neuroinflammatio...
Ganoderma lucidum polysaccharides (Gl-PS) have shown a variety of immune modulating effects. Culture...
Ganoderma lucidum, a fungus native to China, has been widely used to promote health and longevity in...
1 The polysaccharide from Ganoderma lucidum (PS-G) has been reported to enhance immune responses and...
Ganoderma formosanum (GF) is a medicinal mushroom endemic to Taiwan. Previous research established t...
Some cytokines, such as interleukin-2 (IL-2), interferon-gamma (IFN-gamma) and tumor necrosis factor...
Immunomodulation by fungal compounds can be determined by the capacity of the compounds to influence...
Ganoderma lucidum is a medicinal mushroom in China and other Asian countries. The polysaccharide fro...
Differentiation therapy by induction of tumor cells is an important method in the treatment of hemat...