Aim: To investigate whether rimonabant, a cannabinoid receptor antagonist , had inhibitory effects on inflammatory reactions in human umbilical vein endothelial cells (HUVEC). Methods: TNF-alpha-induced IL-6 production was measured by ELISA and effects on related signaling pathways were investigated by immunoblot analysis. Cellular cAMP level was measured using kinase-coupled luciferase reaction. Results: Rimonabant at 1 and 10 mu mol/L significantly inhibited TNF -a-induced IL-6 production when added 15, 30 and 60 minutes before TNF-alpha treatment. Rimonabant also inhibited TNF-a- induced phosphorylation of I kappa B kinase (IKK) alpha/ beta and I kappa B-alpha degradation. ACEA, a cannabinoid receptor subtype 1 (CB1) agonist, added befor...
The endocannabinoid system is a crucial player in the inflammatory processes underlying atherosclero...
Mansour Haddad Faculty of Pharmacy, Philadelphia University, Amman, JordanCorrespondence: Mansour Ha...
Emerging findings suggested the efficacy of the cannabinoid CB1 receptor antagonist rimonabant (SR14...
Aim: To investigate whether rimonabant, a cannabinoid receptor antagonist , had inhibitory effects o...
Background and purpose: Rimonabant (SR141716) is the first selective cannabinoid receptor CB1 antago...
Background and purpose: Rimonabant (SR141716) is the first selective cannabinoid receptor CB1 antago...
The endogenous cannabinoid system plays an important role in regulating the immune system. Modulatio...
ii There is good pharmacological evidence that cannabinoids caused cellular changes by interacting w...
OBJECTIVE: To verify whether synthetic cannabinoids (CP55,940 and WIN55,212-2) are able to exert an ...
The cannabinoid receptor type 1 (CB1) antagonist rimonabant has been used as treatment for obesity. ...
Objective: Angiogenesis depends on a complex interaction between cellular networks and mediators. Th...
The endocannabinoid system is a crucial player in the inflammatory processes underlying atherosclero...
Acyl coenzyme A:cholesterol acyltransferase (ACAT) catalyzes the intracellular synthesis of choleste...
Over the last decades, growing interest has turned to preventive and therapeutic approaches for achi...
The endocannabinoid system is a crucial player in the inflammatory processes underlying atherosclero...
Mansour Haddad Faculty of Pharmacy, Philadelphia University, Amman, JordanCorrespondence: Mansour Ha...
Emerging findings suggested the efficacy of the cannabinoid CB1 receptor antagonist rimonabant (SR14...
Aim: To investigate whether rimonabant, a cannabinoid receptor antagonist , had inhibitory effects o...
Background and purpose: Rimonabant (SR141716) is the first selective cannabinoid receptor CB1 antago...
Background and purpose: Rimonabant (SR141716) is the first selective cannabinoid receptor CB1 antago...
The endogenous cannabinoid system plays an important role in regulating the immune system. Modulatio...
ii There is good pharmacological evidence that cannabinoids caused cellular changes by interacting w...
OBJECTIVE: To verify whether synthetic cannabinoids (CP55,940 and WIN55,212-2) are able to exert an ...
The cannabinoid receptor type 1 (CB1) antagonist rimonabant has been used as treatment for obesity. ...
Objective: Angiogenesis depends on a complex interaction between cellular networks and mediators. Th...
The endocannabinoid system is a crucial player in the inflammatory processes underlying atherosclero...
Acyl coenzyme A:cholesterol acyltransferase (ACAT) catalyzes the intracellular synthesis of choleste...
Over the last decades, growing interest has turned to preventive and therapeutic approaches for achi...
The endocannabinoid system is a crucial player in the inflammatory processes underlying atherosclero...
Mansour Haddad Faculty of Pharmacy, Philadelphia University, Amman, JordanCorrespondence: Mansour Ha...
Emerging findings suggested the efficacy of the cannabinoid CB1 receptor antagonist rimonabant (SR14...