Prognostic Factors of Unknown Primary Head and Neck Squamous Cell Carcinoma

OBJECTIVE: To evaluate the prognostic factors of unknown primary head and neck squamous cell carcinoma (HNSCC). STUDY DESIGN: Retrospective study. SUBJECTS: Patients with unknown primary HNSCC from 1980 to 2000 were included. RESULTS: Forty-eight patients, predominantly male and with a mean age of 63.3+/-11.6 years, were recruited. The median survival time ( MST) was 44 months. The overall survival rate was 60.4 percent at three years and 39.6 percent at five years. Forty-two patients receiving intervention regimens had a MST of 45 months, while six patients receiving palliative therapy had a MST of 8.5 months (log rank test, P =0.016). With multivariate Cox regression analysis, age (per year), higher nodal stage (N3 vs N1 or N2), and treatment ( operation vs nonoperation) had a hazard ratio of 1.081 (P