Association between sequence variant of c.553G>T in the apolipoprotein A5 gene and metabolic syndrome, insulin resistance and carotid atherosclerosis

Common polymorphism of the apolipoprotein A5 gene (APOA5, c. 553 G > 7) related to metabolic syndrome components, insulin resistance, and carotid atherosclerosis remains unclear. We investigated the associations of the APOA5 c.553 G > T gene with various metabolic syndrome components and carotid artery atherosclerosis among family members. A total of 661 participants who provided complete genotyping and carotid artery measures were included in this study. Participants with APOA5 c.553 T carrier (GT and TT) were more likely to have higher levels of triglycerides and apolipoprotein B, as well as lower levels of high-density lipoprotein (HDL ) cholesterol, than participants with the GG genotype. Individuals who carried T alleles had an increased risk of a high level of triglycerides ( multivariate odds ratio (OR), 3.86; 95% confidence interval (CI), 1.98-7. 55; P T polymorphism is associated with high triglycerides and low HDL cholesterol but not with other metabolic syndrome components or carotid atherosclerosis in this ethnic Chinese population