Evidence for Association with Hepatocellular Carcinoma at the Papss1 Locus on Chromosome 4q25 in a Family-Based Study
- 施惟量
- SHIH, WEI-LIANG
DOIAbstract
A region on chromosome 4q25 has recently been highlighted as linked to hepatocellular carcinoma (HCC). In this study, we performed a family-based association analysis with 67 single-nucleotide polymorphisms (SNPs) to map this linkage region in 240 families with HCC, 212 (88.3%) of which were ascertained through hepatitis B virus surface antigen (HBsAg )- positive index cases. Individual SNP analysis with correction for multiple testing identified 10 SNPs in two correlated haplotype blocks, located in or around the 30- phosphoadenosine 50-phosphosulfate synthetase-1 (PAPSS1 ) gene (all P-values: <0.0075). Our linkage data and GIST ( Genotype identity-by-descent sharing test) indicate that 6 of these 10 SNPs contributed to the linkage signal....
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