The Mutation at Position 20210 in the 3'-Untranslated Region of the Prothrombin Gene Is Extremely Rare in Taiwanese Chinese Patients with Venous Thrombophilia

We conducted a case-control study to elucidate the association of prothrombin 20210A mutation with venous thrombophilia in Taiwanese Chiense . One hundred and eleven verified Chinese venous thrombophilic patients and 149 apparently healthy and age-matched individuals without any history of vernous thrombosis were recruited from National Taiwan University Hospital. Prothrombin 20210A mutation was detected by Hind III digestion on PCR-amplified DNA segments . We did not find any heterozygote (G/A) or homozygote (A/A) at position 20210 in venous thrombophilc patients and healthy individuals. We concluded prothrombin 20210A mutation was not an important cause of venous thrombophilia in Chinese