Our previous studies have shown that arsenic trioxide (As2O3 ), a novel anti-cancer agent may be active against urothelial carcinomas. A series of bladder urothelial carcinoma cells with progressive As2O3 resistance were established and studied to reveal molecular events in relation to the mechanisms of resistance to As2O3. A sensitive parental line (NTUB1) and three As2O3-resistant sublines (NTUB1/As) were used with their IC(50)s being 0.9, 1.2, 2.5 and 4.9 muM, respectively. Cellular resistance to As2O 3 was associated with a lowered proliferation profile ( increased p53 and p21(waf1/Cip1) and decreased c-Myc levels) and a greater resistance to apoptosis (elevated Bcl-2 levels). Cells with a stronger resistance had higher expressions of s...
Abstract Background Drinking water contaminated with inorganic arsenic is associated with increased ...
PubMed ID: 11156257We studied the effect of arsenic trioxide (As2O3) on prostate and ovarian carcino...
Arsenic trioxide has recently been shown to inhibit growth and induce apoptosis in a variety of hema...
Arsenic trioxide (AS2O3) is a novel anticancer agent, which has been found to introduce remission in...
Arsenic trioxide (As2O3) has been shown to be an active agent against acute promyelocytic leukemia. ...
Objectives. To explore the therapeutic efficacy of arsenic trioxide (AS(2 )O(3)) in human transition...
<div><p>Previously, arsenic trioxide showed impressive regression rates of acute promyelocytic leuke...
Previously, arsenic trioxide showed impressive regression rates of acute promyelocytic leukemia. Her...
Arsenic is a human bladder carcinogen. Inorganic arsenic and methylated metabolites are excreted fro...
Introduction: Arsenic Trioxide (As2O3) causes antitumor effects by various mechanisms, including deg...
Bladder cancer has been associated with chronic arsenic exposure. Monomethylarsonous acid [MMA(III)]...
Abstract. The effectiveness of As2O3 treatment was studied in 3 carcinoma cell lines, LoVo, OVCAR-3,...
WOS: 000166160200051PubMed ID: 11156257We studied the effect of arsenic trioxide (As2O3) on prostate...
Arsenic trioxide is a traditional remedy in Chinese Medicine since ages. Nowadays, it is clinically ...
Small cell lung carcinoma (SCLC) is an extremely aggressive form of cancer and current treatment pro...
Abstract Background Drinking water contaminated with inorganic arsenic is associated with increased ...
PubMed ID: 11156257We studied the effect of arsenic trioxide (As2O3) on prostate and ovarian carcino...
Arsenic trioxide has recently been shown to inhibit growth and induce apoptosis in a variety of hema...
Arsenic trioxide (AS2O3) is a novel anticancer agent, which has been found to introduce remission in...
Arsenic trioxide (As2O3) has been shown to be an active agent against acute promyelocytic leukemia. ...
Objectives. To explore the therapeutic efficacy of arsenic trioxide (AS(2 )O(3)) in human transition...
<div><p>Previously, arsenic trioxide showed impressive regression rates of acute promyelocytic leuke...
Previously, arsenic trioxide showed impressive regression rates of acute promyelocytic leukemia. Her...
Arsenic is a human bladder carcinogen. Inorganic arsenic and methylated metabolites are excreted fro...
Introduction: Arsenic Trioxide (As2O3) causes antitumor effects by various mechanisms, including deg...
Bladder cancer has been associated with chronic arsenic exposure. Monomethylarsonous acid [MMA(III)]...
Abstract. The effectiveness of As2O3 treatment was studied in 3 carcinoma cell lines, LoVo, OVCAR-3,...
WOS: 000166160200051PubMed ID: 11156257We studied the effect of arsenic trioxide (As2O3) on prostate...
Arsenic trioxide is a traditional remedy in Chinese Medicine since ages. Nowadays, it is clinically ...
Small cell lung carcinoma (SCLC) is an extremely aggressive form of cancer and current treatment pro...
Abstract Background Drinking water contaminated with inorganic arsenic is associated with increased ...
PubMed ID: 11156257We studied the effect of arsenic trioxide (As2O3) on prostate and ovarian carcino...
Arsenic trioxide has recently been shown to inhibit growth and induce apoptosis in a variety of hema...