Prenatal Three-Dimensional/Four-Dimensional Sonographic Demonstration of Facial Dysmorphisms Associated with Holoprosencephaly

In this report, we describe the prenatal use of 3- dimensional 4- dimensional (3D/4D) sonography to visualize the facial dysmorphisms associated with holoprosencephaly in 6 fetuses (2 with cyclopia, 1 with cebocephaly, and 3 with holoprosencephaly-premaxillary agenesis). Ultrafast MRI was also used. The 3D/4D sonographic images allowed easy, rapid, and precise prenatal evalua-tion of the facial dysmorphisms associated with holoprosencephaly; the MRI scans provided little additional information. The 3D/4D sonograms helped the parents visualize the abnormalities and facilitated their acceptance of perinatal genetic counseling. © 2005 Wiley Periodicals, Inc. J Clin Ultrasound 33:312- 318, 200