Mismatch of the minor histocompatibility antigen HB-1 has been shown to correlate with graft-versus-host disease in HLA matched sibling marrow transplants. The HA-1(H) peptide (VLHDDLLEA) that generates this response is known to be presented by HLA-A*0201. In order to understand the interaction of HA-1 peptides with other HLA-A alleles, we have used the LOOK interface to construct molecular models of both HA-1(H) pcp tide ( VLHDDLLEA) and HA-1(R) peptide ( VLRDDLLEA) binding with 103 HLA-A alleles . The results show that in addition to A*0201, 21/103 other HLA-A alleles should be able to bind HA-1H peptide but not HA-1R peptide. Based on the modeled predictions, HLA alleles on be categorised into 4 groups with respect to their interaction w...
Background. The minor histocompatibility antigen HA-1 occurs in two allelic forms: H and R. The HA-1...
Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA m...
Human minor histocompatibility antigens (mHags) play an important role in the induction of cytotoxic...
Human minor histocompatibility antigens (mHag) are target antigens of the graft-versus-leukemia resp...
The polymorphic minor histocompatibility Ag HA-1 locus encodes two peptides, HA-1H and HA-1R, with a...
Minor histocompatibility antigens (mHAg) composed of peptides presented by HLA molecules can cause i...
Minor histocompatibility antigens (mHAs), recipient-derived peptide epitopes presented on the cell s...
BACKGROUND: Allogeneic bone marrow donors can be incompatible at different levels. Even HLA-identica...
Donor T-cell mediated graft versus host (GVH) effects may result from the aggregate alloreactivity t...
Graft-versus-host disease (GvHD) can be a major complication of allogeneic bone marrow transplantati...
Human Leukocyte Antigen (HLA) class I is a group of genes located on human chromosome 6 which play a...
Copyright © 2014 Heike Kunze-Schumacher et al. This is an open access article distributed under the ...
Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA m...
Item does not contain fulltextHuman minor histocompatibility antigens (mHags) play an important role...
AbstractWe explored the relationship between individual human leukocyte antigens (HLAs) and the risk...
Background. The minor histocompatibility antigen HA-1 occurs in two allelic forms: H and R. The HA-1...
Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA m...
Human minor histocompatibility antigens (mHags) play an important role in the induction of cytotoxic...
Human minor histocompatibility antigens (mHag) are target antigens of the graft-versus-leukemia resp...
The polymorphic minor histocompatibility Ag HA-1 locus encodes two peptides, HA-1H and HA-1R, with a...
Minor histocompatibility antigens (mHAg) composed of peptides presented by HLA molecules can cause i...
Minor histocompatibility antigens (mHAs), recipient-derived peptide epitopes presented on the cell s...
BACKGROUND: Allogeneic bone marrow donors can be incompatible at different levels. Even HLA-identica...
Donor T-cell mediated graft versus host (GVH) effects may result from the aggregate alloreactivity t...
Graft-versus-host disease (GvHD) can be a major complication of allogeneic bone marrow transplantati...
Human Leukocyte Antigen (HLA) class I is a group of genes located on human chromosome 6 which play a...
Copyright © 2014 Heike Kunze-Schumacher et al. This is an open access article distributed under the ...
Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA m...
Item does not contain fulltextHuman minor histocompatibility antigens (mHags) play an important role...
AbstractWe explored the relationship between individual human leukocyte antigens (HLAs) and the risk...
Background. The minor histocompatibility antigen HA-1 occurs in two allelic forms: H and R. The HA-1...
Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA m...
Human minor histocompatibility antigens (mHags) play an important role in the induction of cytotoxic...