APOA1/C3/A5 haplotype and risk of hypertriglyceridemia in Taiwanese

Background: Apolipoprotein A5 gene (APOA5) has been shown to modulate plasma triglyceride concentrations. We investigated 2 distinct APOA1/C3/A5 haplotypes roles for hypertriglyceridemia. Methods: We recruited 308 cases of hypertriglyceridemia and 281 normal controls from a hospital . Twelve single nucleotide polymorphisms (SNPs) across the APOA1/C3/A5 gene region were genotyped. Results: One haplotype containing the minor alleles of the APOA5 (-1131T> C, c.553G>T) and APOA1 (-3013C>T,-75G>A) was more prevalent in cases than in controls (11.3% vs. 1.1%, respectively) and was statistically significantly associated with high triglycerides (adjusted odds ratio: 12.83, 95% confidence interval [CI]: 5.1-32.4, P