Chemical and Anti-Platelet Constituents from Formosan Zanthoxylum Simulans

A pyrrole alkaloid, pyrrolezanthine [5-hydroxymethyl-1-[2-(4 - hydroxyphenyl)-ethyl]-1H-pyrrole-2-carbaldehyde]; a lignan, (-)-simulanol [4- [3-hydroxymethyl-5-((E)-3-hydroxypropenyl) -7-methoxy-2,3- dihydrobenzofuran-2-yl]-2,6-dimethoxy-phenol] and a monocyclic gamma- pyrone, zanthopyranone [3,5- dimethoxy-2-methyl-pyran-4-one], together with 28 known compounds were isolated from the stem wood of Formosan Zanthoxylum simulans. Their structures were determined through spectral analyses. Among the isolates, 11 compounds showed anti-platelet aggregation activity in vitro. (C) 2002 Elsevier Science Ltd. All rights reserved