Structure and-Function of Bovine Pancreatic Deoxyribonuclease I

Bovine pancreatic deoxyribonuclehse I (bpDNase), the first DNase discovered, is the best characterized among various types of DNase, A catalytic mechanism has been suggested based on the X-ray structure of the bpDNase-octamer complex. In this review, we will focus on three aspects: 1) the distinctive functions of the two structural calcium atoms; 2 ) the biological functions of the two disulfides; and 3) the involvement of the N- and C-terminal fragments in the enzyme folding for activity