Therapeutic Effect of Liver Resection in Patients with Metastatic Liver Tumors

Thirty-five hepatectomies for metastatic liver malignancy were performed from January 1986 to July 1992 at the National Taiwan University Hospital. Taiwan University Hospital. Twenty-six of them were of colorectal origin and nine were of other origins. We analyzed the risk factors for recurrence and survival rate affter hepatectomy of colorectal origin under curative intention with both univariate and multivariate analysia. The calculated median disease free interval after hepatectomy was 11 months( recurrence rate 65% in one year and 85% in two years). The median survival rate was 24 months (calculated one-year survival survival 86%, two-year survival 41%). In univariate analysis, the number of metastatic lesions and operation procedures significantly affect the recurrence rate (p=0.033 and p=0.042, respectively). In survival univariate analysis , only a safety margin > 1 cm and age > 50 years had significant benefit (p=0.0014 and p=0.045, respectively). By multivariate analysis, only solitary metastasis was beneficial to the recurrence rate ( p=0.013), an age > 50 years had a borderline beneficial effect to the recurrence rate (p=0.052), while earlier liver stage, older age, larger safety margin and minor operative procedures positively affected the survival rate (=0.039, 0.018, 0.034 and 0.017, respectively). As the sample number was small, it was hard to draw any conclusions for metastatic liver tumors of other origins. The complication rate (5/35) and mortality rate (1 /35) of hepatectomy were low. We concluded that for selected cases of metastatic hepatic malignancy, especially from colorectal cancer, hepatectomy is a promising treatment of choic.#0689