Exposure of cells to phorbol ester activates protein kinase C (PKC) to induce apoptosis or differentiation, depending on the cellular context. In erythroblastic cell lines, TF-1 and D2, upregulation of the RhoA signaling promotes phorbol ester-induced apoptosis through activating Rho- associated kinase (ROCK)/phosphorylation of myosin light chain (MLC), thus generating membrane contraction force. As a result, cell adhesion is inhibited and death receptor-mediated death pathway is activated in these cells with a concurrent changes in nucleocytoplasmic signaling for protein trafficking. A microtubule-regulated GEF-H1, which is a specific RhoA activator, was identified to contribute to RhoA activation in these cells. Thus, a cytoskeleton- regu...
<p><b>(A)</b> Co-immunoprecipitation of ERK and p-ERK with RhoA. COS-7 cells expressing GFP-RhoA wer...
Cardiovascular disease (CVD) continues to be the primary cause of global mortality. Vascular smooth ...
The RhoA GTPase plays a vital role in assembly of contractile actin- myosin filaments (stress fibers...
Phorbol-12-myristate-13-acetate (PMA) treatment induces erythroblastoma D2 cells kept in suspension ...
In certain Rasmutant cell lines, the inhibition of extracellular signal-regulated kinase (ERK) signa...
The small GTPase RhoA has been implicated in various cellular activities, including the formation of...
Apoptotic cells undergo a number of changes to prepare for phagocytosis; most occur during the execu...
The regulation of cell morphology is a dynamic process under the control of multiple protein complex...
Platelets are released by megakaryocytes (MKs) via cytoplasmic extensions called proplatelets, which...
The regulation of cell morphology is a dynamic process under the control of multiple protein complex...
The killing and removal of superfluous cells is an important step during embryonic development, tiss...
<div><p>The regulation of cell morphology is a dynamic process under the control of multiple protein...
The Rho family small GTPases are key regulators of the cytoskeleton, through which they impact and c...
In certain Ras mutant cell lines, the inhibition of extracellular signal-regulated kinase (ERK) sign...
Transforming RhoA proteins (RHOA) and their downstream Diaphanous homolog 1 proteins (DIAPH1) or mDi...
<p><b>(A)</b> Co-immunoprecipitation of ERK and p-ERK with RhoA. COS-7 cells expressing GFP-RhoA wer...
Cardiovascular disease (CVD) continues to be the primary cause of global mortality. Vascular smooth ...
The RhoA GTPase plays a vital role in assembly of contractile actin- myosin filaments (stress fibers...
Phorbol-12-myristate-13-acetate (PMA) treatment induces erythroblastoma D2 cells kept in suspension ...
In certain Rasmutant cell lines, the inhibition of extracellular signal-regulated kinase (ERK) signa...
The small GTPase RhoA has been implicated in various cellular activities, including the formation of...
Apoptotic cells undergo a number of changes to prepare for phagocytosis; most occur during the execu...
The regulation of cell morphology is a dynamic process under the control of multiple protein complex...
Platelets are released by megakaryocytes (MKs) via cytoplasmic extensions called proplatelets, which...
The regulation of cell morphology is a dynamic process under the control of multiple protein complex...
The killing and removal of superfluous cells is an important step during embryonic development, tiss...
<div><p>The regulation of cell morphology is a dynamic process under the control of multiple protein...
The Rho family small GTPases are key regulators of the cytoskeleton, through which they impact and c...
In certain Ras mutant cell lines, the inhibition of extracellular signal-regulated kinase (ERK) sign...
Transforming RhoA proteins (RHOA) and their downstream Diaphanous homolog 1 proteins (DIAPH1) or mDi...
<p><b>(A)</b> Co-immunoprecipitation of ERK and p-ERK with RhoA. COS-7 cells expressing GFP-RhoA wer...
Cardiovascular disease (CVD) continues to be the primary cause of global mortality. Vascular smooth ...
The RhoA GTPase plays a vital role in assembly of contractile actin- myosin filaments (stress fibers...