Selective intermolecular zero-quantum coherence in high-resolution NMR under inhomogeneous fields

A selective 2D intermolecular zero-quantum coherences pulse sequence, SEL-HOMOGENIZED sequence, was developed for high-resolution NMR spectra in inhomogeneous fields. The sequence designed to effectively suppress strong solvent signals & other trivial signals can greatly decrease the t1 noise artifacts. In the homogeneous-like 1D spectrum extracted from the 2D data, chemical shifts, coupling constants, multiplicity patterns, & relative peak areas are almost independent of the magnetic field inhomogeneity. Compared to the HOMOGENIZED sequence, the new sequence provides a total sensitivity enhancement of two times. It was also demonstrated that the theoretical predictions were in excellent agreement with the experimental results