Prions are a group of proteins that can adopt a spectrum of metastable conformations in vivo. These alternative states change protein function and are self-replicating and transmissible, creating protein-based elements of inheritance and infectivity. Prion conformational flexibility is encoded in the amino acid composition and sequence of the protein, which dictate its ability not only to form an ordered aggregate known as amyloid but also to maintain and transmit this structure in vivo. But, while we can effectively predict amyloid propensity in vitro, the mechanism by which sequence elements promote prion propagation in vivo remains unclear. In yeast, propagation of the [PSI+] prion, the amyloid form of the Sup35 protein, has been linked ...
SummaryYeast prions are self-templating protein-based mechanisms of inheritance whose conformational...
Altres ajuts: ICREA-Academia 2015 to S.V.Prion-like behaviour is attracting much attention due to th...
Prions are self-perpetuating proteinaceous agents that are associated with degenerative neurological...
Prions are a group of proteins that can adopt a spectrum of metastable conformations in vivo. These ...
Prions are a group of proteins that can adopt a spectrum of metastable conformations in vivo. These ...
AbstractThe yeast [PSI+] factor propagates by a prion-like mechanism involving self-replicating Sup3...
Many proteins can misfold into beta-sheet-rich, self-seeding polymers (amyloids). Prions are excepti...
The unusual genetic properties of the non-chromosomal genetic elements [URE3] and [PSI+] led to them...
Despite major efforts devoted to understanding the phenomenon of prion transmissibility, it is still...
<div><p>Amyloidogenic proteins associated with a variety of unrelated diseases are typically capable...
<div><p>Many proteins can misfold into β-sheet-rich, self-seeding polymers (amyloids). Prions are ex...
Proteins are built based on a DNA sequence template and fold into distinctive shapes or conformation...
Amyloidogenic proteins associated with a variety of unrelated diseases are typically capable of form...
Amyloids consist of repetitions of a specific polypeptide chain in a regular cross-β-sheet conformat...
Multiple yeast prions have been identified that result from the structural conversion of proteins in...
SummaryYeast prions are self-templating protein-based mechanisms of inheritance whose conformational...
Altres ajuts: ICREA-Academia 2015 to S.V.Prion-like behaviour is attracting much attention due to th...
Prions are self-perpetuating proteinaceous agents that are associated with degenerative neurological...
Prions are a group of proteins that can adopt a spectrum of metastable conformations in vivo. These ...
Prions are a group of proteins that can adopt a spectrum of metastable conformations in vivo. These ...
AbstractThe yeast [PSI+] factor propagates by a prion-like mechanism involving self-replicating Sup3...
Many proteins can misfold into beta-sheet-rich, self-seeding polymers (amyloids). Prions are excepti...
The unusual genetic properties of the non-chromosomal genetic elements [URE3] and [PSI+] led to them...
Despite major efforts devoted to understanding the phenomenon of prion transmissibility, it is still...
<div><p>Amyloidogenic proteins associated with a variety of unrelated diseases are typically capable...
<div><p>Many proteins can misfold into β-sheet-rich, self-seeding polymers (amyloids). Prions are ex...
Proteins are built based on a DNA sequence template and fold into distinctive shapes or conformation...
Amyloidogenic proteins associated with a variety of unrelated diseases are typically capable of form...
Amyloids consist of repetitions of a specific polypeptide chain in a regular cross-β-sheet conformat...
Multiple yeast prions have been identified that result from the structural conversion of proteins in...
SummaryYeast prions are self-templating protein-based mechanisms of inheritance whose conformational...
Altres ajuts: ICREA-Academia 2015 to S.V.Prion-like behaviour is attracting much attention due to th...
Prions are self-perpetuating proteinaceous agents that are associated with degenerative neurological...