Design and characterization of a combined OCT and wide field imaging falloposcope for ovarian cancer detection

Early detection of ovarian cancer is only achieved in around 20% of women due to lack of effective screening. We propose a method for surveillance of high risk women based on a microendoscope introduced transvaginally to image the fallopian tubes and ovaries. This requires extreme miniaturization of the optics and catheter sheath. We describe the design of a falloposcope that combines optical coherence tomography (OCT) and wide field imaging into a sub-1 mm diameter package. We characterize the systems and show that they provide contrast on ex-vivo samples of ovary and fallopian tube. In addition, we show the mechanical performance of the endoscope in an anatomically correct model of the female reproductive tract. (C) 2016 Optical Society of AmericaDepartment of Defense [W81XWH-13-1-0131]; National Institutes of Health/ National Institute of Biomedical Imaging and Bioengineering [U54EB015403]; Arizona Technology Research Innovation Fund Imaging Fellowship; Achievement Rewards for College Scientists (ARCS) Phoenix ChapterOpen access journal.This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu