Add to ORKGUncontrolled or non-resolving inflammation underpins a range of disease states including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. Hypoxia is a prominent feature of chronically inflamed tissues. This is due to elevated oxygen consumption by highly metabolically active inflamed resident cells and activated infiltrating immunocytes, as well as diminished oxygen supply due to vascular dysfunction. Tissue hypoxia can have a significant impact upon inflammatory signaling pathways in immune and non-immune cells and this can impact upon disease progression. In this review, we will discuss the relationship between tissue hypoxia and inflammation and identify how hypoxia-sensitive signaling pathways are potential therapeu...
With little in the way of effective therapeutic strategies to target the innate immune response, a b...
Hypoxia is a hallmark of inflamed, infected or damaged tissue, and the adaptation to inadequate tiss...
Two main features common to all solid tumors are tissue hypoxia and inflammation, both of which caus...
Uncontrolled or non-resolving inflammation underpins a range of disease states including rheumatoid ...
Uncontrolled inflammation underpins a diverse range of diseases where effective therapy remains an u...
Hypoxia and inflammation are frequently co-incidental features of the tissue microenvironment in a w...
Hypoxia‐inducible factors (HIFs) have emerged in recent years as critical regulators of immunity. Lo...
The gastrointestinal tract (GI) has a unique oxygenation profile. It should be noted that the state ...
Mammals have developed evolutionarily conserved programs of transcriptional response to hypoxia and ...
Oxygen availability varies throughout the human body in health and disease. Under physiological cond...
Hypoxia is a prominent characteristic of many acute or chronic inflammatory diseases, and exerts sig...
Induction and activation of nitric oxide (NO) synthases (NOS) and excessive production of NO are com...
Many inflammatory diseases are characterised by persistent and inappropriate neutrophil activation, ...
Intestinal epithelial cells that line the mucosal surface of the gastrointestinal tract are position...
The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible factor (HIF...
With little in the way of effective therapeutic strategies to target the innate immune response, a b...
Hypoxia is a hallmark of inflamed, infected or damaged tissue, and the adaptation to inadequate tiss...
Two main features common to all solid tumors are tissue hypoxia and inflammation, both of which caus...
Uncontrolled or non-resolving inflammation underpins a range of disease states including rheumatoid ...
Uncontrolled inflammation underpins a diverse range of diseases where effective therapy remains an u...
Hypoxia and inflammation are frequently co-incidental features of the tissue microenvironment in a w...
Hypoxia‐inducible factors (HIFs) have emerged in recent years as critical regulators of immunity. Lo...
The gastrointestinal tract (GI) has a unique oxygenation profile. It should be noted that the state ...
Mammals have developed evolutionarily conserved programs of transcriptional response to hypoxia and ...
Oxygen availability varies throughout the human body in health and disease. Under physiological cond...
Hypoxia is a prominent characteristic of many acute or chronic inflammatory diseases, and exerts sig...
Induction and activation of nitric oxide (NO) synthases (NOS) and excessive production of NO are com...
Many inflammatory diseases are characterised by persistent and inappropriate neutrophil activation, ...
Intestinal epithelial cells that line the mucosal surface of the gastrointestinal tract are position...
The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible factor (HIF...
With little in the way of effective therapeutic strategies to target the innate immune response, a b...
Hypoxia is a hallmark of inflamed, infected or damaged tissue, and the adaptation to inadequate tiss...
Two main features common to all solid tumors are tissue hypoxia and inflammation, both of which caus...