THESIS 8579The development of small organic molecules capable of mimicking enzymatic action (in an asymmetric catalysis context) is a challenge that is receiving widespread attention in contemporary organic chemistry. Herein we report the design and synthesis of a new class of chiral 4-N,N-dialkyaminopyridine acyl-transfer catalysts capable of exploiting both van der Waals (?) and H-bonding interactions to allow remote chiral information to stereochemically control the kinetic resolution of a diverse range (both aromatic and aliphatic) sec-alcohols with moderate to excellent selectivity (S = 6 - 30). A combination of optimisation, substrate screening, catalyst modification, spectroscopic and computational studies have clearly identified bot...
The present article summarizes the development of two novel and complementary catalytic methods to a...
Controlling the absolute stereochemistry of molecules is a major challenge to contemporary chemists....
Lewis base catalysis has been studied extensively in recent years as a powerful tool for introducing...
Organocatalysis using small organic molecules to catalyze organic transformations, has emerged as a ...
A new chiral 4-(dimethylamino)pyridine (DMAP) analog was developed that used restricted rotation to ...
The mechanism of esterification of the secondary alcohol 1-(1-naphthyl)ethanol <b>9</b> by isobutyr...
A one step Pd-catalyzed coupling methodology involving a reaction between a chiral diamine and a 2-b...
Acyl-transfer reactions have become commonplace in organic synthesis and organocatalysis of these re...
4-dimethylaminopyridine (DMAP) is an extremely versatile catalyst active in a large series of chemic...
The research described in this thesis focuses on the catalytic acylative kinetic resolution (KR) of ...
THESIS 6702Chapter 1 of this thesis discusses the explosion of interest in the non-enzymatic kinetic...
The present article summarizes the development of two novel and complementary catalytic methods to a...
Catalytic transfer hydrogenation of ketones in alcohol solvents has much promise in pharmaceutical s...
Graduation date: 2016Complex organic transformations, such as the addition of pyrrole to ketene usin...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2002.Vita.Includes bibli...
The present article summarizes the development of two novel and complementary catalytic methods to a...
Controlling the absolute stereochemistry of molecules is a major challenge to contemporary chemists....
Lewis base catalysis has been studied extensively in recent years as a powerful tool for introducing...
Organocatalysis using small organic molecules to catalyze organic transformations, has emerged as a ...
A new chiral 4-(dimethylamino)pyridine (DMAP) analog was developed that used restricted rotation to ...
The mechanism of esterification of the secondary alcohol 1-(1-naphthyl)ethanol <b>9</b> by isobutyr...
A one step Pd-catalyzed coupling methodology involving a reaction between a chiral diamine and a 2-b...
Acyl-transfer reactions have become commonplace in organic synthesis and organocatalysis of these re...
4-dimethylaminopyridine (DMAP) is an extremely versatile catalyst active in a large series of chemic...
The research described in this thesis focuses on the catalytic acylative kinetic resolution (KR) of ...
THESIS 6702Chapter 1 of this thesis discusses the explosion of interest in the non-enzymatic kinetic...
The present article summarizes the development of two novel and complementary catalytic methods to a...
Catalytic transfer hydrogenation of ketones in alcohol solvents has much promise in pharmaceutical s...
Graduation date: 2016Complex organic transformations, such as the addition of pyrrole to ketene usin...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2002.Vita.Includes bibli...
The present article summarizes the development of two novel and complementary catalytic methods to a...
Controlling the absolute stereochemistry of molecules is a major challenge to contemporary chemists....
Lewis base catalysis has been studied extensively in recent years as a powerful tool for introducing...