Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for use as a pharmaceutical excipient. It is used in pharmaceutical coating of solid oral dosage forms such as coated tablets or capsules. However, the information of ATBC on its pharmacokinetics is limited. The aim of this study is to investigate the pharmacokinetic properties of ATBC using liquid chromatography-tandem mass spectrometric (LC-MS/MS) analysis. ATBC was rapidly absorbed and eliminated and the bioavailability was 27.4% in rats. The results of metabolic stability tests revealed that metabolic clearance may have accounted for a considerable portion of the total clearance of ATBC. These pharmacokinetic data would be useful in studies in...
Ugilec 141 is a technical mixture of tetrachlorobenzyltoluenes (TCBTs). It was introduced in the ear...
Cancer claims millions of lives per year. In an effort to find cures to cancer, scientists have tur...
The liver is an important organ for drugs disposition, and thus how to accurately evaluate hepatic c...
Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for u...
The article aimed to study intestinal absorption and pharmacokinetic characterization of three atrac...
The purpose of this study was to measure the pharmacokinetics and tissue accumulation of N-acetylami...
A simple and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was devel-oped a...
Acapha®, an herbal product used for treating esophageal cancer in China, is undergoing clinical tria...
This thesis investigates the potential of some commonly used pharmaceutical excipients to alter drug...
JinQi Jiangtang (JQJT) tablets, a Chinese patent medicine approved by the State Food and Drug Admini...
β-cyclodextrin has a unique annular hollow ultrastructure that allows encapsulation of various poorl...
Purpose: Knowledge of the blood pharmacokinetics of monoclonal antibodies is crucial in deciding the...
Purpose: This study was undertaken to examine the disposition of COL-3, a chemically modified tetrac...
ADB-CHMINACA (MAB-CHMINACA) is a new synthetic cannabinoid with high potency and many reported adver...
Copyright © 2014 Yan Huo et al.This is an open access article distributed under the Creative Commons...
Ugilec 141 is a technical mixture of tetrachlorobenzyltoluenes (TCBTs). It was introduced in the ear...
Cancer claims millions of lives per year. In an effort to find cures to cancer, scientists have tur...
The liver is an important organ for drugs disposition, and thus how to accurately evaluate hepatic c...
Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for u...
The article aimed to study intestinal absorption and pharmacokinetic characterization of three atrac...
The purpose of this study was to measure the pharmacokinetics and tissue accumulation of N-acetylami...
A simple and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was devel-oped a...
Acapha®, an herbal product used for treating esophageal cancer in China, is undergoing clinical tria...
This thesis investigates the potential of some commonly used pharmaceutical excipients to alter drug...
JinQi Jiangtang (JQJT) tablets, a Chinese patent medicine approved by the State Food and Drug Admini...
β-cyclodextrin has a unique annular hollow ultrastructure that allows encapsulation of various poorl...
Purpose: Knowledge of the blood pharmacokinetics of monoclonal antibodies is crucial in deciding the...
Purpose: This study was undertaken to examine the disposition of COL-3, a chemically modified tetrac...
ADB-CHMINACA (MAB-CHMINACA) is a new synthetic cannabinoid with high potency and many reported adver...
Copyright © 2014 Yan Huo et al.This is an open access article distributed under the Creative Commons...
Ugilec 141 is a technical mixture of tetrachlorobenzyltoluenes (TCBTs). It was introduced in the ear...
Cancer claims millions of lives per year. In an effort to find cures to cancer, scientists have tur...
The liver is an important organ for drugs disposition, and thus how to accurately evaluate hepatic c...