Charakterisierung von Zytokinantworten und Gedächtniszell-Populationen mittels Multi-Farben-Durchflusszytometrie

  • Direito de Morais Guerreiro, Manuel Nuno
Publication date
January 2014

Abstract

The recent advances in flowcytometry have come hand-in-hand with an improved knowledge of the immune system, and with practical and clinical benefits. Given the need to answer immunological and clinically relevant questions, a flowcytometry-based approach that focuses on the assessment of cytokine secretion and memory markers in different settings was established. The Epstein-Barr Virus (EBV)-specific T cell memory analysis revealed the existence of six subsets at distinct differentiation stages. The memory T cell profile of a protective immune-response against a chronic infection was delineated, providing a basis for analyzing T cell responses in EBV-associated diseases. The enhanced frequencies of multifunctional and cytotoxic EBV- specif...

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